模板:PBB/2064

V-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
PDB rendering based on 1n8z.
有效结构 PDB 直系同源检索：PDBe, RCSB PDB查询代码列表 1MFG, 1MFL, 1MW4, 1N8Z, 1QR1, 1S78, 2A91, 2JWA, 2KS1, 2L4K, 3BE1, 3H3B, 3MZW, 3N85, 3PP0, 3RCD
标识
代号	ERBB2; CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1
扩展标识	遗传学：164870 鼠基因：95410 同源基因：3273 ChEMBL: 1824 GeneCards: ERBB2 Gene
EC编号	2.7.10.1
基因本体论描述 分子功能 · RNA polymerase I core binding · protein tyrosine kinase activity · transmembrane receptor protein tyrosine kinase activity · receptor signaling protein tyrosine kinase activity · transmembrane signaling receptor activity · epidermal growth factor-activated receptor activity · protein binding · ATP binding · protein C-terminus binding · growth factor binding · protein phosphatase binding · identical protein binding · ErbB-3 class receptor binding · protein heterodimerization activity · protein dimerization activity 细胞成分 · nucleus · plasma membrane · endosome membrane · integral to membrane · basolateral plasma membrane · apical plasma membrane · receptor complex · perinuclear region of cytoplasm 生物过程 · positive regulation of protein phosphorylation · transcription, DNA-dependent · protein phosphorylation · signal transduction · cell surface receptor signaling pathway · enzyme linked receptor protein signaling pathway · transmembrane receptor protein tyrosine kinase signaling pathway · epidermal growth factor receptor signaling pathway · nervous system development · axon guidance · peripheral nervous system development · heart development · neuromuscular junction development · motor neuron axon guidance · cell proliferation · fibroblast growth factor receptor signaling pathway · phosphatidylinositol 3-kinase cascade · signal transduction by phosphorylation · positive regulation of cell growth · mammary gland development · positive regulation of Rho GTPase activity · regulation of microtubule-based process · negative regulation of immature T cell proliferation in thymus · wound healing · myelination · positive regulation of MAP kinase activity · innate immune response · positive regulation of translation · regulation of angiogenesis · positive regulation of cell adhesion · positive regulation of transcription from RNA polymerase I promoter · positive regulation of transcription from RNA polymerase III promoter · protein autophosphorylation · neurotrophin TRK receptor signaling pathway · phosphatidylinositol-mediated signaling · positive regulation of epithelial cell proliferation · regulation of ERK1 and ERK2 cascade Sources: Amigo / QuickGO
RNA表达模式
更多表达数据
直系同源体
物种	人类	鼠类
Entrez	2064	13866
Ensembl	ENSG00000141736	ENSMUSG00000062312
UniProt	P04626	P70424
mRNA序列	NM_001005862	NM_001003817
蛋白序列	NP_001005862	NP_001003817
基因位置	Chr 17: 37.84 – 37.89 Mb	Chr 11: 98.41 – 98.44 Mb
PubMed查询	[1]	[2]