14.36.39.47：建立内容为“{{PBB|geneid=1956}} '''表皮生长因子受体'''（{{lang-en|epidermal growth factor receptor}}，简称为'''EGFR'''、'''ErbB-1'''或'''HER1'''）是一…”的新页面

2021-07-21T18:25:40Z

建立内容为“{{PBB|geneid=1956}} '''表皮生长因子受体'''（{{lang-en|epidermal growth factor receptor}}，简称为'''EGFR'''、'''ErbB-1'''或'''HER1'''）是一…”的新页面

新页面

{{PBB|geneid=1956}}
'''表皮生长因子受体'''（{{lang-en|epidermal growth factor receptor}}，简称为'''EGFR'''、'''[[ErbB]]-1'''或'''HER1'''）是一类名为[[表皮生长因子]]家族（EGF-家族）的[[细胞]]外[[蛋白]][[配体 (生物化学)|配体]]的[[细胞膜|细胞表面]][[受体 (生物化学)|受体]]<ref name="pmid15142631">{{cite journal | author = Herbst RS | title = Review of epidermal growth factor receptor biology | journal = Int. J. Radiat. Oncol. Biol. Phys. | volume = 59 | issue = 2 Suppl | pages = 21–6 | year = 2004 | pmid = 15142631 | doi = 10.1016/j.ijrobp.2003.11.041 }}</ref> 。

表皮生长因子受体是[[ErbB|ErbB受体家族]]家族的成员之一，ErbB家族是包含四种紧密联系蛋白的亚家族，这四种蛋白分别是[[受体]][[酪氨酸]][[激酶类]]：EGFR（ErbB-1）[[HER2/neu|HER2/c-neu]]（ErbB-2）、[[ERBB3|Her 3]]（ErbB-3）以及Her 4（ErbB-4）。影响EGFR表达或活性的[[突变]]可能导致[[癌症]]<ref name="pmid17671639">{{cite journal | author = Zhang H, Berezov A, Wang Q, Zhang G, Drebin J, Murali R, Greene MI | title = ErbB receptors: from oncogenes to targeted cancer therapies | journal = J. Clin. Invest. | volume = 117 | issue = 8 | pages = 2051–8 | year = 2007 | month = August | pmid = 17671639 | pmc = 1934579 | doi = 10.1172/JCI32278 }}</ref>。

表皮生长因子及其受体是由范德堡大学的斯坦利·科恩发现的，科恩与丽塔·列维-蒙塔尔奇尼因发现[[生长因子]]类而共同获得了1986年[[诺贝尔生理学或医学奖]]。

== 功能 ==

[[Image:EGFR signaling pathway (zh-cn).svg|left|thumb|EGFR信号传导级联]] 表皮生长因子受体（EGFR）存在于[[细胞表面]]且因结合特异性受体而被激活，这些受体包括表皮生长因子和TGFα。ErbB2并无已知的直接激活[[配体]]，可能结构性地处于激活状态，或在与如EGFR等其他家族成员形成[[异源二聚体]]时被激活。

==参考文献==

{{Reflist|2}}

==深入阅读==

{{refbegin | 2}}
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*
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{{refend}}

==外部链接==
* {{MeshName|Epidermal+Growth+Factor+Receptor|3=Epidermal Growth Factor Receptor}}

{{PDB Gallery|geneid=1956}}
{{酪氨酸激酶类}}
{{癌基因}}
{{酶联受体}}
{{生长因子受体}}

[[Category:酪氨酸激酶受体]]

[[Category:癌基因]]

{{Link GA|ja}}
==参考来源==
*[http://zh.wikipedia.org/wiki/%E8%A1%A8%E7%9A%AE%E7%94%9F%E9%95%BF%E5%9B%A0%E5%AD%90%E5%8F%97%E4%BD%93 维基百科-表皮生长因子受体]

表皮生长因子受体 - 版本历史

14.36.39.47：建立内容为“{{PBB|geneid=1956}} '''表皮生长因子受体'''（{{lang-en|epidermal growth factor receptor}}，简称为'''EGFR'''、'''ErbB-1'''或'''HER1'''）是一…”的新页面