https://www.yiliao.com/index.php?action=history&feed=atom&title=%E8%91%A1%E8%90%84%E7%B3%96-6-%E7%A3%B7%E9%85%B8%E8%84%B1%E6%B0%A2%E9%85%B6 2026-04-22T17:12:21Z 本wiki的该页面的版本历史 MediaWiki 1.35.1 https://www.yiliao.com/index.php?title=%E8%91%A1%E8%90%84%E7%B3%96-6-%E7%A3%B7%E9%85%B8%E8%84%B1%E6%B0%A2%E9%85%B6&diff=306584&oldid=prev 2021-07-21T19:20:54Z

<p>建立内容为“{{Template:PBB/2539}} {{enzyme | Name = 葡萄糖-6-磷酸脱氢酶 | Systematic_name = D-glucose-6-phosphate:NADP&lt;sup&gt;+&lt;/sup&gt; 1-oxidoreductase | Acronym = G6PDH;…”的新页面</p> <p><b>新页面</b></p><div>{{Template:PBB/2539}}<br /> {{enzyme<br /> | Name = 葡萄糖-6-磷酸脱氢酶<br /> | Systematic_name = D-glucose-6-phosphate:NADP&lt;sup&gt;+&lt;/sup&gt; 1-oxidoreductase<br /> | Acronym = G6PDH; GPD<br /> | Other_names = NADP-glucose-6-phosphate dehydrogenase; Zwischenferment; D-glucose 6-phosphate dehydrogenase; glucose 6-phosphate dehydrogenase (NADP); NADP-dependent glucose 6-phosphate dehydrogenase; 6-phosphoglucose dehydrogenase; Entner-Doudoroff enzyme; glucose-6-phosphate 1-dehydrogenase<br /> | EC_number = 1.1.1.49<br /> | CAS_number = 9001-40-5 | IUBMB_EC_number = 1/1/1/49 | GO_code = 0004345 | image = Protein_G6PD_PDB_1qki.png<br /> | width = <br /> | caption = 葡萄糖-6-磷酸脱氢酶结构（[[蛋白质数据库|PDB]] 1qki）<br /> }}<br /> '''葡萄糖-6-磷酸脱氢酶'''（{{lang-en|glucose-6-phosphate dehydrogenase}}，[[EC编号|EC]] [http://enzyme.expasy.org/EC/1.1.1.49 1.1.1.49]）是一种以[[烟酰胺腺嘌呤二核苷酸|NAD&lt;sup&gt;+&lt;/sup&gt;]]或[[烟酰胺腺嘌呤二核苷酸磷酸|NADP&lt;sup&gt;+&lt;/sup&gt;]]为[[受体 (生物化学)|受体]]、作用于[[供体]][[次甲基|CH]]-[[羟基|OH]]基团上的[[氧化还原酶]]。这种酶能[[催化]]以下[[酶促反应]]：<br /> <br /> :[[D-葡萄糖-6-磷酸]] + [[烟酰胺腺嘌呤二核苷酸磷酸|NADP&lt;sup&gt;+&lt;/sup&gt;]] &lt;math&gt;\rightleftharpoons&lt;/math&gt; [[6-磷酸葡糖酸内酯|D-葡萄糖酸-1,5-内酯-6-磷酸]] + NADPH + [[氢离子|H&lt;sup&gt;+&lt;/sup&gt;]]<br /> <br /> 葡萄糖-6-磷酸脱氢酶主要参与[[磷酸戊糖途径]]，也能缓慢地作用在β-D-[[葡萄糖]]等其他[[糖类]]上。这种酶可由其[[底物]][[葡萄糖-6-磷酸]]激活，如果人类[[基因表达|表达]]葡萄糖-6-磷酸脱氢酶的[[基因]][[G6PD]]有缺陷，将会导致葡萄糖-6-[[磷酸脱氢酶缺乏症]]，引发非[[免疫|免疫性]][[溶血性贫血]]。葡萄糖-6-磷酸脱氢酶存在于众多生物[[细胞]]内，[[高等植物]]拥有数种葡萄糖-6-磷酸脱氢酶的[[蛋白]][[异构体]]（protein isoform），它们分布于[[细胞质基质]]、和[[过氧化物酶体]]等细胞结构中。&lt;ref&gt;{{cite journal | first = | last = Corpas FJ et al. | title = A dehydrogenase-mediated recycling system of NADPH in plant peroxisomes | journal = Biochem. J. | year = 1998 | volume = 330 | issue = 7 | pages = 777–784 | doi = }}&lt;/ref&gt;<br /> <br /> == 参考文献 ==<br /> <br /> {{reflist}}<br /> {{refbegin}}<br /> *{{cite journal | author=Vulliamy T, Beutler E, Luzzatto L |title=Variants of glucose-6-phosphate dehydrogenase are due to missense mutations spread throughout the coding region of the gene. |journal=Hum. Mutat. |volume=2 |issue= 3 |pages= 159–67 |year= 1993 |pmid= 8364584 |doi= 10.1002/humu.1380020302 }}{{wordbreak}}<br /> *{{cite journal | author=Mason PJ |title=New insights into G6PD deficiency. |journal=Br. J. Haematol. |volume=94 |issue= 4 |pages= 585–91 |year= 1996 |pmid= 8826878 |doi= }}{{wordbreak}}<br /> *{{cite journal | author=Wajcman H, Galactéros F |title=[Glucose 6-phosphate dehydrogenase deficiency: a protection against malaria and a risk for hemolytic accidents] |journal=C. R. Biol. |volume=327 |issue= 8 |pages= 711–20 |year= 2004 |pmid= 15506519 |doi= }}{{wordbreak}}<br /> {{PDB Gallery|geneid=2539}}<br /> {{refend}}<br /> <br /> {{EC 1.1}}<br /> <br /> [[Category:EC 1.1.1]] [[Category:NADPH依赖性酶]] [[Category:已知结构的酶]]<br /> ==参考来源==<br /> *[http://zh.wikipedia.org/wiki/%E8%91%A1%E8%90%84%E7%B3%96-6-%E7%A3%B7%E9%85%B8%E8%84%B1%E6%B0%A2%E9%85%B6 维基百科-葡萄糖-6-磷酸脱氢酶]</div>

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