112.247.67.26：以“{{Hierarchy header}}

{| class="wikitable" |- | | 药物 | | 生物利用度（%） | | 尿排泄（%） | | 血浆蛋白结合（%） | |...”为内容创建页面

2014-02-06T08:08:57Z

以“{{Hierarchy header}} <br /> <div> {| class="wikitable" |- | | 药物 | | 生物利用度（%） | | 尿排泄（%） | | 血浆蛋白结合（%） | |...”为内容创建页面

新页面

{{Hierarchy header}}
<br />

<div>

{| class="wikitable"
|-
| | 药物
| | [[生物利用度]]（%）
| | 尿[[排泄]]（%）
| | [[血浆蛋白结合]]（%）
| | 清除率（ml.min<sup>-1</sup>.kg<sup>-1</sup>）
| | 分布容积（L/kg）
| | 半衰期（h）
|-
| | [[醋丁洛尔]] acebutolol
| | 37
| | 40
| | 26
| | 6.8
| | 1.2
| | 2.7
|-
| | [[阿昔洛韦]] aciclovir
| | 15～30
| | 75
| | 15
| | 3.37
| | 0.69
| | 2.4
|-
| | [[别嘌醇]] allopurinol
| | 80～90
| | &lt;10
| | &lt;1
| | 12.7
| | 0.6～1.6
| | 1～3
|-
| | [[阿普洛尔]] alprenolol
| | 8.6
| | 0.2
| | 85
| | 15
| | 3.3
| | 2.5
|-
| | [[金刚烷胺]] amantadine
| | 50～90
| | 50～90
| | 67
| | 4.8
| | 6.6
| | 16
|-
| | [[两性霉素B]] amphotericin B
| | -
| | 2～5
| | &gt;90
| | 0.46
| | 0.76
| | 18
|-
| | [[阿米卡星]] amikacin
| | -
| | 98
| | 4
| | 1.3
| | 0.27
| | 2.3
|-
| | [[胺碘酮]] amiodarone
| | 46
| | 0
| | 100
| | 1.9
| | 66
| | 25d
|-
| | [[阿米替林]] amitriptyline
| | 48
| | &lt;2
| | 94.8
| | 11.5
| | 15
| | 21.5
|-
| | [[氨苄西林]] ampicillin
| | 62
| | 82
| | 18
| | 1.7
| | 0.28
| | 1.3
|-
| | [[阿斯匹林]] aspirin
| | 68
| | 1.4
| | 49
| | 9.3
| | 0.15
| | 0.25
|-
| | [[阿替洛尔]] atenolol
| | 56
| | 94
| | &lt;5
| | 2.4
| | 0.95
| | 6.1
|-
| | [[阿曲库铵]] atracurium
| | -
| | &lt;1
| | -
| | 5.5
| | 0.16
| | 0.33
|-
| | [[阿托品]] atropine
| | 50
| | 57
| | 14～22
| | 5.9
| | 1.7
| | 4.3
|-
| | [[硫唑嘌呤]] azathioprine
| | 60
| | &lt;2
| | -
| | 57
| | 0.81
| | 0.16
|-
| | [[倍他米松]] betamethasone
| | 72
| | 4.8
| | 64
| | 2.9
| | 1.4
| | 5.6
|-
| | [[博莱霉素]] bleomycin
| | -
| | 68
| | -
| | 1.1
| | 0.27
| | 3.1
|-
| | [[布美他尼]] bumetanide
| | 81
| | 62
| | 99
| | 2.6
| | 0.13
| | 0.8
|-
| | [[布比卡因]] bupivacaine
| | -
| | 2
| | 95
| | 7.1
| | 0.9
| | 2.4
|-
| | [[咖啡因]] caffeine
| | 100
| | 1.1
| | 36
| | 1.4
| | 0.61
| | 4.9
|-
| | [[卡托普利]] captopril
| | 65
| | 38
| | 30
| | 12
| | 0.81
| | 2.2
|-
| | [[卡马西平]] carbamazepine
| | &gt;70
| | &lt;1
| | 74
| | 1.3
| | 1.4
| | 15
|-
| | [[羧苄西林]] carbenicillin
| | -
| | 82
| | 50
| | 0.68
| | 0.18
| | 1.0
|-
| | [[头孢克洛]] cefaclor
| | -
| | 52
| | 25
| | 6.1
| | 0.36
| | 0.67
|-
| | [[头孢氨苄]] cefalexin
| | 90
| | 91
| | 14
| | 4.3
| | 0.26
| | 0.9
|-
| | [[头孢孟多]] cefamandole
| | -
| | 96
| | 74
| | 2.8
| | 0.16
| | 0.78
|-
| | [[头孢唑林]] cefazolin
| | -
| | 80
| | 89
| | 0.95
| | 0.12
| | 1.8
|-
| | [[头孢哌酮]] cefoperazone
| | -
| | 29
| | 89～93
| | 1.2
| | 0.09
| | 2.1
|-
| | [[头孢噻肟]] cefotaxime
| | -
| | 50
| | 36
| | 3.7
| | 0.23
| | 1.1
|-
| | [[头孢拉定]] cefradine
| | &gt;90
| | 86
| | 14
| | 5.1
| | 0.25
| | 0.77
|-
| | [[头孢曲松]] ceftriaxone
| | -
| | 46
| | 90～95
| | 0.24
| | 0.16
| | 7.3
|-
| | [[头孢呋辛]] cefuroxime
| | -
| | 96
| | 33
| | 0.94
| | 0.19
| | 1.7
|-
| | [[苯丁酸氮芥]] chlorambucil
| | 87
| | &lt;1
| | 99
| | 2.6
| | 0.29
| | 1.3
|-
| | [[氯霉素]] chloramphenicol
| | 75～90
| | 25
| | 53
| | 2.4
| | 0.94
| | 4.0
|-
| | [[氯喹]] chloroquine
| | 89
| | 61
| | 61
| | 1.8
| | 115
| | 41
|-
| | [[氯噻嗪]] chlorothiazide
| | 9～56
| | 92
| | 94.6
| | 4.5
| | 0.20
| | 1.5
|-
| | [[氯丙嗪]] chlorpromazine
| | 32
| | 〈1
| | 95～98
| | 8．6
| | 21
| | 30
|-
| | 氯酞酮 chlortalidone
| | 64
| | 65
| | 75
| | 1.6
| | 3.9
| | 44
|-
| | [[西米替丁]] cimetidine
| | 62
| | 62
| | 19
| | 8.3
| | 1.0
| | 2.0
|-
| | [[环丙沙星]] ciprofloxacin
| | 60
| | 65
| | 40
| | 6.0
| | 1.8
| | 4.1
|-
| | [[顺铂]] cisplatin
| | -
| | 23
| | -
| | 6.3
| | 0.28
| | 0.53
|-
| | 氯贝特 clofibrate
| | 95
| | 5.7
| | 96.5
| | 0.12
| | 0.11
| | 13
|-
| | [[氯硝西泮]] clonazepam
| | 98
| | &lt;1
| | 86
| | 1.55
| | 3.2
| | 23
|-
| | [[可乐定]] clonidine
| | 95
| | 62
| | 20
| | 3.1
| | 2.1
| | 12
|-
| | [[可卡因]] cocaine
| | 57
| | &lt;2
| | 91
| | 32
| | 2.0
| | 0.8
|-
| | [[可待因]] codeine
| | 50
| | 0
| | 7
| | 11
| | 2.6
| | 2.9
|-
| | [[环磷酰胺]] cyclophosphamide
| | 74
| | 6.5
| | 13
| | 1.3
| | 0.78
| | 7.5
|-
| | 环孢霉素 cyclosporine
| | 23
| | &lt;1
| | 93
| | 5.9
| | 1.2
| | 5.6
|-
| | [[氨苯砜]] dapsone
| | 93
| | 15
| | 73
| | 0.6
| | 1.0
| | 22
|-
| | [[地塞米松]] dexamethasone
| | 78
| | 2.6
| | 68
| | 3.7
| | 0.82
| | 3.0
|-
| | [[地西泮]] diazepam
| | 100
| | &lt;1
| | 98.7
| | 0.38
| | 1.1
| | 43
|-
| | [[洋地黄毒甙]] digitoxin
| | &gt;90
| | 32
| | 97
| | 0.055
| | 0.54
| | 6.7d
|-
| | [[地高辛]] digoxin
| | 70
| | 60
| | 25
| | 0.88
| | -
| | 39
|-
| |
[[地尔硫]]

{{图片|gnubt7st.gif|}} diltiazem
| | 44
| | &lt;4
| | 78
| | 12
| | 3.1
| | 3.7
|-
| | [[苯海拉明]] diphenhydramine
| | 72
| | 1.9
| | 78
| | 6.2
| | 4.5
| | 8.5
|-
| | [[丙吡胺]] disopyramide
| | 83
| | 55
| | -
| | 1.2
| | 0.59
| | 6.0
|-
| | [[多巴酚丁胺]] dobutamine
| | -
| | -
| | -
| | 59
| | 0.2
| | 2.4
|-
| | [[阿霉素]] doxorublicin
| | 5
| | &lt;15
| | 79～85
| | 17
| | 25
| | 30
|-
| | [[多西环素]] doxycycline
| | 93
| | 41
| | 88
| | 0.53
| | 0.75
| | 16
|-
| | [[依那普利]] enalapril
| | 41
| | 88
| | &lt;50
| | 4.9
| | 1.7
| | 11
|-
| | [[依诺沙星]] enoxacin
| | 79
| | 60
| | 0
| | -
| | -
| | 5
|-
| | [[红霉素]] erythromycin
| | 35
| | 12
| | 84
| | 9.1
| | 0.78
| | 1.6
|-
| | [[艾司洛尔]] esmolol
| | -
| | &lt;1
| | 55
| | 170
| | 1.9
| | 0.13
|-
| | [[乙胺丁醇]] ethambutol
| | 77
| | 79
| | &lt;5
| | 8.6
| | 1.6
| | 3.1
|-
| | [[乙醇]] ethanol
| | 80
| | &lt;3
| | -
| | -
| | 0.54
| | 0.24
|-
| | [[炔雌醇]] ethinylestradiol
| | 40
| | -
| | 98
| | 6.3
| | 1.5～4.3
| | 6～20
|-
| | [[法莫替丁]] famotidine
| | 45
| | 67
| | 17
| | 7.1
| | 1.3
| | 2.6
|-
| | [[芬太尼]] fentanyl
| | -
| | 8
| | 84
| | 13
| | 4.0
| | 3.7
|-
| | [[氟卡尼]] flecainide
| | 70
| | 43
| | 61
| | 5.6
| | 4.9
| | 11
|-
| | [[氟氯西林]] flucloxacillin
| | 49
| | 41
| | 96
| | -
| | 0.11
| | 0.8
|-
| | [[氟尿嘧啶]] fluorouracil
| | 28
| | &lt;10
| | 8～12
| | 16
| | 0.25
| | 11
|-
| | [[氟奋乃静]] fluphenazine
| | -
| | -
| | -
| | -
| | 20
| | 14.7～15.3
|-
| | [[呋噻米]] furosemide
| | 61
| | 66
| | 98.8
| | 2.0
| | 0.11
| | 92
|-
| | [[庆大霉素]] gentamicin
| | -
| | &gt;90
| | &lt;10
| | 0.82
| | 0.31
| | 2～3
|-
| | [[格列本脲]] glibenclamide
| | 90
| | 1
| | 99
| | 1.5
| | 0.12
| | 1.6
|-
| | [[胍乙啶]] guanethidine
| | 35
| | 43
| | 0
| | -
| | 60
| | 120
|-
| | [[氟哌啶醇]] haloperidol
| | 61
| | 1
| | 92
| | 11.8
| | 18
| | 18
|-
| | [[肝素]] heparin
| | -
| | 0
| | -
| | -
| | 0.058
| | 12
|-
| | [[肼屈嗪]] hydralazine
| | 16～35
| | 1～15
| | 87
| | 56
| | 1.5
| | 0.96
|-
| | [[氢氯噻嗪]] hydrochlorothiazide
| | 71
| | &gt;95
| | 58
| | 4.9
| | 0.83
| | 2.5
|-
| | [[氢化可的松]] hydrocortisone
| | -
| | &lt;1
| | 90～95
| | -
| | -
| | 1～2
|-
| | [[布洛芬]] ibuprofen
| | &gt;80
| | &lt;1
| | &gt;99
| | 0.75
| | 0.15
| | 2
|-
| | [[米帕明]] imipramine
| | 40
| | &lt;2
| | 90.1
| | 15
| | 23
| | 18
|-
| | [[吲哚美辛]] indometacin
| | 98
| | 15
| | 90
| | 2.0
| | 0.26
| | 2.4
|-
| | [[胰岛素]] insulin
| | -
| | &lt;2
| | 5
| | -
| | 0.08
| | 0.1～0.3
|-
| | [[异烟肼]] isoniazid
| | -
| | 7～29
| | 0
| | 3.7～7.4
| | 0.67
| | 1.1～3.1
|-
| | [[硝酸异山梨酯]] isosorbide dinitrate
| | 22～30
| | &lt;1
| | 28
| | 45
| | 1.5
| | 0.8
|-
| | [[5-单硝酸异山梨酯]] isosorbide-5-mononitrate
| | 93
| | &lt;5
| | 0
| | 1.81
| | 0.79
| | 4.4
|-
| | [[卡那霉素]] kanamycin
| | -
| | 90
| | 0
| | 1.4
| | 0.26
| | 2.1
|-
| | [[酮康唑]] ketoconazole
| | -
| | &lt;1
| | 99
| | 8.4
| | 2.4
| | 3.3
|-
| | [[拉贝洛尔]] labetalol
| | 18
| | &lt;5
| | 50
| | 25
| | 9.4
| | 4.9
|-
| | [[左旋多巴]] levodopa
| | -
| | -
| | -
| | 7.7～13
| | 0.8～1.1
| | 2.2
|-
| | [[利多卡因]] lidocaine
| | 35
| | 2
| | 70
| | 9.2
| | 1.1
| | 1.8
|-
| | [[林可霉素]] lincomycin
| | 100
| | 20
| | 72
| | -
| | 0.44
| | 5
|-
| | 锂盐 lithium
| | 100
| | 95
| | 0
| | 0.35
| | 0.79
| | 22
|-
| | [[洛伐他汀]] lovastatin
| | 5
| | &lt;10
| | 95
| | 5～21
| | -
| | 1.1～1.7
|-
| | [[巯嘌呤]] mercaptopurine
| | 12
| | 22
| | 19
| | 11
| | 0.56
| | 0.9
|-
| | [[美沙酮]] methadone
| | 92
| | 24
| | 89
| | 1.4
| | 3.8
| | 35
|-
| | [[甲氨蝶呤]] methotrexate
| | 70
| | 48
| | 34
| | 2.1
| | 0.55
| | 7.2
|-
| | [[甲氧氯普胺]] metoclopramide
| | 76
| | 20
| | 40
| | 6.2
| | 3.4
| | 5.0
|-
| | [[美托洛尔]] metoprolol
| | 38
| | 10
| | 11
| | 15
| | 4.2
| | 3.2
|-
| | [[甲硝唑]] metronidazole
| | 99
| | 10
| | 10
| | 1.3
| | 0.74
| | 8.5
|-
| | [[美西律]] mexiletine
| | 87
| | 4～15
| | 63
| | 6.3
| | 4.9
| | 9.2
|-
| | [[米诺环素]] minocycline
| | 95～100
| | 11
| | 76
| | 1.0
| | 1.3
| | 16
|-
| | [[米诺地尔]] minoxidil
| | -
| | 20
| | 0
| | 24
| | 2.7
| | 3.1
|-
| | [[吗啡]] morphine
| | 24
| | 6～10
| | 35
| | 24
| | 3.3
| | 1.9
|-
| | [[纳多洛尔]] nadolol
| | 34
| | 73
| | 20
| | 2.9
| | 1.9
| | 16
|-
| | [[纳洛酮]] naloxone
| | 2
| | 0
| | -
| | 22
| | 2.1
| | 1.1
|-
| | [[萘普生]] naproxen
| | 99
| | &lt;1
| | 99.7
| | 0.13
| | 0.16
| | 14
|-
| | [[新斯的明]] neostigmine
| | -
| | 67
| | -
| | 8.4
| | 0.7
| | 1.3
|-
| | [[尼卡地平]] nicardipine
| | 19～38
| | &lt;1
| | 89～99.5
| | 13.4
| | 1.1
| | 1.3
|-
| | [[硝苯地平]] nifedipine
| | 50
| | 0
| | 96
| | 7.0
| | 0.78
| | 1.8
|-
| | [[硝西泮]] nitrazepam
| | 78
| | &lt;1
| | 87
| | 0.86
| | 1.9
| | 26
|-
| | [[硝酸甘油]] nitroglycerin
| | &lt;1
| | &lt;1
| | -
| | 230
| | 3.3
| | 2.3min
|-
| | [[炔诺酮]] norethisterone
| | 65
| | -
| | 80
| | -
| | 1.5～4.3
| | 5～14
|-
| | [[诺氟沙星]] norfloxacin
| | 30～40
| | 26～32
| | 15～20
| | 7.2
| | 3.2
| | 5
|-
| | [[奥美拉唑]] omeprazole
| | -
| | &lt;1
| | 95
| | -
| | 0.19～0.48
| | 1～2.3
|-
| | [[昂丹司琼]] ondansetron
| | 60
| | &lt;10
| | 70～76
| | 10～12
| | 2.3
| | 3～3.5
|-
| | [[对乙酰氨基酚]] paracetamol
| | 88
| | 3
| | 0
| | 5.0
| | 0.95
| | 2.0
|-
| | [[培氟沙星]] pefloxacin
| | 1
| | &lt;10
| | 20～30
| | 2.3
| | 1.5～1.9
| | 7～14
|-
| | [[青霉素G]] penicillin G
| | 22
| | 70
| | 60
| | -
| | 0.2
| | 0.6
|-
| | [[青霉素V]] penicillin V
| | 60～73
| | 26～65
| | 75～89
| | -
| | 0.5
| | 0.5
|-
| | [[戊巴比妥]] pentobarbital
| | &gt;90
| | &lt;1
| | 35～45
| | 0.8
| | 1
| | 35～45
|-
| | [[哌替啶]] pethidine
| | 52
| | 1～25
| | 58
| | 17
| | 4.4
| | 3.2
|-
| | [[苯巴比妥]] phenobarbital
| | 100
| | 24
| | 51
| | 0.062
| | 0.54
| | 99
|-
| | [[保泰松]] phenybutazone
| | 80～100
| | 1
| | 96.1
| | 0.023
| | 0.097
| | 56
|-
| | [[苯妥英]] phenytoin
| | 90
| | 2
| | 89
| | -
| | 0.64
| | 6～24
|-
| | [[吲哚洛尔]] pindolol
| | 75
| | 54
| | 51
| | 8.3
| | 2.3
| | 3.6
|-
| | [[哌拉西林]] piperacillin
| | -
| | 71
| | 16～48
| | 2.6
| | 0.18
| | 0.93
|-
| | [[吡罗昔康]] piroxicam
| | -
| | &lt;5
| | 99.3
| | 0.036
| | 0.15
| | 48
|-
| | [[哌唑嗪]] prazosin
| | 68
| | &lt;1
| | 95
| | 3.0
| | 0.6
| | 2.9
|-
| | [[泼尼松龙]] prednisolone
| | 82
| | 26
| | 90～95
| | 8.7
| | 1.5
| | 2.2
|-
| | [[泼尼松]] prednisone
| | 80
| | 3
| | 75
| | 3.6
| | 0.97
| | 3.6
|-
| | [[普鲁卡因胺]] procainamide
| | 83
| | 67
| | 16
| | 2.7
| | 1.9
| | 3.0
|-
| | [[异丙嗪]] promethazine
| | -
| | -
| | 70～80
| | 18
| | 13
| | 12
|-
| | [[普罗帕酮]] propafenone
| | 3～40
| | &lt;1
| | 97
| | -
| | -
| | 9～25(PM) 3～8(EM)
|-
| | [[普萘洛尔]] propafenone
| | 26
| | &lt;0.5
| | 87
| | 16
| | 4.3
| | 3.9
|-
| | [[乙胺嘧啶]] pyrimethamine
| | -
| | 65
| | 87
| | 0.41
| | 2.9
| | 83
|-
| | [[奎尼丁]] quinidine
| | 80
| | 18
| | 87
| | 4.7
| | 2.7
| | 6.2
|-
| | [[雷尼替丁]] ranitidine
| | 52
| | 69
| | 15
| | 10.4
| | 1.3
| | 2.1
|-
| | [[利福平]] rifampin
| | -
| | 7
| | 89
| | 3.5
| | 0.97
| | 3.5
|-
| | [[东莨菪碱]] scopolamine
| | 27
| | 6
| | -
| | 16
| | 1.4
| | 2.9
|-
| | [[索他洛尔]] sotalol
| | 60
| | 60
| | 54
| | -
| | 0.7
| | 9
|-
| | [[链激酶]] streptokinase
| | -
| | 0
| | -
| | 0.15
| | 0.016
| | 1.4
|-
| | [[链霉素]] streptomycin
| | -
| | 50～60
| | 48
| | 1.2
| | 0.25
| | 2.6
|-
| | [[磺胺嘧啶]] sulfadiazine
| | 100
| | 57
| | 54
| | 0.55
| | 0.29
| | 9.9
|-
| | [[磺胺异恶唑]] sulfafurazole
| | 96
| | 49
| | 91.4
| | 0.33
| | 0.15
| | 6.6
|-
| | [[磺胺甲恶唑]] sulfamethoxazol
| | 100
| | 14
| | 62
| | 0.32
| | 0.21
| | 10.1
|-
| | [[舒林酸]] sulindac
| | -
| | 0
| | 99.4
| | 1.5
| | 2
| | 15
|-
| | [[特布他林]] terbutaline
| | 14
| | 56
| | 20
| | 3.4
| | 1.8
| | 14
|-
| | 硫喷妥 thiopental
| | -
| | &lt;1
| | 85
| | 3.9
| | 2.3
| | 9.0
|-
| | [[替卡西林]] ticarcillin
| | -
| | 92
| | 65
| | 2.0
| | 0.21
| | 1.3
|-
| | 噻马洛尔 timolol
| | 50
| | 15
| | 60
| | 7.3
| | 2.1
| | 4.1
|-
| | [[妥布霉素]] tobramycin
| | -
| | 90
| | &lt;10
| | 0.98
| | 0.33
| | 2.2
|-
| | [[甲苯磺丁脲]] tolbutamide
| | 93
| | 0
| | 96
| | 0.24
| | 0.10
| | 5.9
|-
| | [[氨苯蝶啶]] triamterene
| | 54
| | 52
| | 61
| | 63
| | 13.4
| | 4.2
|-
| | [[筒箭毒碱]] tubocurarine
| | -
| | 63
| | 50
| | 1.9
| | 0.39
| | 2.0
|-
| | [[万古霉素]] vancomycin
| | -
| | 79
| | 30
| | 1.4
| | 0.39
| | 5.6
|-
| | [[维库溴铵]] vecuronium bromide
| | -
| | 18
| | 30
| | 3.0
| | 2.1
| | 1.5
|-
| | [[维拉帕米]] verapamil
| | 22
| | &lt;3
| | 90
| | 15
| | 5
| | 4.0
|-
| | [[华法林]] warfarin
| | 93
| | &lt;2
| | 99
| | 0.045
| | 0.14
| | 37
|}

本表资简化自①A.G.Gilman et al(ed):Goodman and Gilman’s Thepharmacological basis of therapeuties. 8th ed.Macmillan,1990:1655～1715.

②Melmon K.L.andMorrelli:Clinical pharmacology.3rd ed.Mcgraw-Hill,1992:1029～1072.

③Herfindal E.T.etal:Clinical pharmacy and Therapeutics.3rd ed.1992:364～368.

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药理学/附录某些药物代谢动力学数据 - 版本历史

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