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米氏方程 - 版本历史
2026-04-09T21:49:24Z
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2026年2月4日 (三) 00:24 77921020
2026-02-04T00:24:40Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">←上一版本</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">2026年2月4日 (三) 00:24的版本</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l61" >第61行：</td>
<td colspan="2" class="diff-lineno">第61行：</td></tr>
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<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <p style="margin: 15px 0; text-align: justify;"></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <p style="margin: 15px 0; text-align: justify;"></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> 米氏方程以简洁的数学形式描述了酶促反应速率 (v) 如何依赖于底物浓度 ([S])：</div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> 米氏方程以简洁的数学形式描述了酶促反应速率 (<ins class="diffchange diffchange-inline"><i></ins>v<ins class="diffchange diffchange-inline"></i></ins>) 如何依赖于底物浓度 ([S])：</div></td></tr>
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<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <div style="background-color: #f0f9ff; border-left: 5px solid #1e40af; padding: 20px; margin: 25px 0; border-radius: 4px; text-align: center;"></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <div style="background-color: #f0f9ff; border-left: 5px solid #1e40af; padding: 20px; margin: 25px 0; border-radius: 4px; text-align: center;"></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <div style="font-size: 1.5em; font-family: 'Times New Roman', Times, serif; color: #1e3a8a; margin-bottom: 15px;"></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <div style="font-size: 1.5em; font-family: 'Times New Roman', Times, serif; color: #1e3a8a; margin-bottom: 15px<ins class="diffchange diffchange-inline">; display: flex; align-items: center; justify-content: center</ins>;"></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <del class="diffchange diffchange-inline">$$ </del>v = <del class="diffchange diffchange-inline">\frac{V_{</del>max<del class="diffchange diffchange-inline">} </del>[S]<del class="diffchange diffchange-inline">}{K_m </del>+ [S]<del class="diffchange diffchange-inline">} $$</del></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <ins class="diffchange diffchange-inline"><span style="font-style: italic; margin-right: 10px;"></ins>v<ins class="diffchange diffchange-inline"></span> = </ins></div></td></tr>
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<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> <div style</ins>=<ins class="diffchange diffchange-inline">"border-bottom: 2px solid #1e3a8a; padding-bottom: 3px; margin-bottom: 3px;"></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> <i>V</i><sub></ins>max<ins class="diffchange diffchange-inline"></sub> </ins>[S]</div></td></tr>
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<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> <div></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> <i>K</i><sub>m</sub> </ins>+ [S]</div></td></tr>
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<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> </div></ins></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </div></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </div></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <div style="font-size: 0.9em; color: #475569; text-align: left; margin-top: <del class="diffchange diffchange-inline">15px</del>; border-top: 1px solid #cbd5e1; padding-top: 10px;"></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <div style="font-size: 0.9em; color: #475569; text-align: left; margin-top: <ins class="diffchange diffchange-inline">20px</ins>; border-top: 1px solid #cbd5e1; padding-top: 10px;"></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <strong>其中：</strong><br></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <strong>其中：</strong><br></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> • <strong>V<sub>max</sub>：</strong> 酶被底物完全饱和时的最大反应速率。<br></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> • <strong>V<sub>max</sub>：</strong> 酶被底物完全饱和时的最大反应速率。<br></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> • <strong>K<sub>m</sub>：</strong> 反应速率达到最大速率一半 (<del class="diffchange diffchange-inline">$V_{</del>max<del class="diffchange diffchange-inline">}</del>/2<del class="diffchange diffchange-inline">$</del>) 时的底物浓度。</div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> • <strong>K<sub>m</sub>：</strong> 反应速率达到最大速率一半 (<ins class="diffchange diffchange-inline">V<sub></ins>max<ins class="diffchange diffchange-inline"></sub> </ins>/ 2) 时的底物浓度。</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </div></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </div></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </div></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </div></div></td></tr>
<tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l102" >第102行：</td>
<td colspan="2" class="diff-lineno">第110行：</td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: 10px; border: 1px solid #cbd5e1; font-weight: 600;">初速度条件<br>(Initial Rate)</td></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: 10px; border: 1px solid #cbd5e1; font-weight: 600;">初速度条件<br>(Initial Rate)</td></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: 10px; border: 1px solid #cbd5e1;"></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: 10px; border: 1px solid #cbd5e1;"></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> 仅测量反应刚开始时的速率 (<del class="diffchange diffchange-inline">$v_0$</del>)。此时产物 [P] 极少，可以忽略逆反应 (P &rarr; S)。</div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> 仅测量反应刚开始时的速率 (<ins class="diffchange diffchange-inline"><i>v</i><sub>0</sub></ins>)。此时产物 [P] 极少，可以忽略逆反应 (P &rarr; S)。</div></td></tr>
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77921020
https://www.yiliao.com/index.php?title=%E7%B1%B3%E6%B0%8F%E6%96%B9%E7%A8%8B&diff=316363&oldid=prev
77921020：建立内容为“<div style="padding: 0 4%; line-height: 1.8; color: #1e293b; font-family: 'Helvetica Neue', Helvetica, 'PingFang SC', Arial, sans-serif; background-color: #ffffff…”的新页面
2026-02-04T00:21:49Z
<p>建立内容为“<div style="padding: 0 4%; line-height: 1.8; color: #1e293b; font-family: 'Helvetica Neue', Helvetica, 'PingFang SC', Arial, sans-serif; background-color: #ffffff…”的新页面</p>
<p><b>新页面</b></p><div><div style="padding: 0 4%; line-height: 1.8; color: #1e293b; font-family: 'Helvetica Neue', Helvetica, 'PingFang SC', Arial, sans-serif; background-color: #ffffff; max-width: 1200px; margin: auto;"><br />
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<strong>米氏方程</strong>（Michaelis-Menten Equation）是生物化学中最著名、应用最广泛的速率方程之一。它由德国生物化学家 Leonor Michaelis 和加拿大医生 Maud Menten 于 1913 年提出，用于描述<strong>单底物酶促反应</strong>的速率与底物浓度之间的定量关系。该方程揭示了酶促反应的<strong>饱和效应</strong>：即在低底物浓度下反应速率随浓度线性增加，而在高底物浓度下速率趋于一个极限值（<strong>V<sub>max</sub></strong>）。米氏方程不仅是<strong>[[酶动力学]]</strong>的理论基石，也是药理学中计算药物亲和力和代谢速率的核心工具。<br />
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<div style="font-size: 1.2em; font-weight: bold; letter-spacing: 1.2px;">米氏方程</div><br />
<div style="font-size: 0.7em; opacity: 0.85; margin-top: 4px; white-space: nowrap;">Michaelis-Menten Equation (点击展开)</div><br />
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<div style="font-size: 0.8em; color: #64748b; margin-top: 12px; font-weight: 600;">双曲线模型：v vs [S]</div><br />
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<th colspan="2" style="padding: 8px 12px; background-color: #e0f2fe; color: #1e40af; text-align: left; font-size: 0.9em; border-top: 1px solid #bae6fd;">方程属性</th><br />
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<th style="text-align: left; padding: 6px 12px; background-color: #f8fafc; color: #475569; border-bottom: 1px solid #e2e8f0; width: 45%;">提出年份</th><br />
<td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #0f172a;">1913年</td><br />
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<th style="text-align: left; padding: 6px 12px; background-color: #f8fafc; color: #475569; border-bottom: 1px solid #e2e8f0;">适用范围</th><br />
<td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #1e40af;">简单的单底物反应</td><br />
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<th style="text-align: left; padding: 6px 12px; background-color: #f8fafc; color: #475569; border-bottom: 1px solid #e2e8f0;">曲线形状</th><br />
<td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #16a34a;">矩形双曲线</td><br />
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<th colspan="2" style="padding: 8px 12px; background-color: #e0f2fe; color: #1e40af; text-align: left; font-size: 0.9em; border-top: 1px solid #bae6fd;">关键变量</th><br />
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<th style="text-align: left; padding: 6px 12px; background-color: #f8fafc; color: #475569; border-bottom: 1px solid #e2e8f0;">v (Velocity)</th><br />
<td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #0f172a;">初始反应速率</td><br />
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<th style="text-align: left; padding: 6px 12px; background-color: #f8fafc; color: #475569; border-bottom: 1px solid #e2e8f0;">[S]</th><br />
<td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #1e40af;">底物浓度</td><br />
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<th style="text-align: left; padding: 6px 12px; background-color: #f8fafc; color: #475569;">K<sub>m</sub></th><br />
<td style="padding: 6px 12px; color: #e11d48;">米氏常数 (亲和力)</td><br />
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<h2 style="background: #f1f5f9; color: #0f172a; padding: 10px 18px; border-radius: 0 6px 6px 0; font-size: 1.25em; margin-top: 40px; border-left: 6px solid #0f172a; font-weight: bold;">方程表达式与几何意义</h2><br />
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米氏方程以简洁的数学形式描述了酶促反应速率 (v) 如何依赖于底物浓度 ([S])：<br />
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$$ v = \frac{V_{max} [S]}{K_m + [S]} $$<br />
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<strong>其中：</strong><br><br />
• <strong>V<sub>max</sub>：</strong> 酶被底物完全饱和时的最大反应速率。<br><br />
• <strong>K<sub>m</sub>：</strong> 反应速率达到最大速率一半 ($V_{max}/2$) 时的底物浓度。<br />
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<h2 style="background: #f1f5f9; color: #0f172a; padding: 10px 18px; border-radius: 0 6px 6px 0; font-size: 1.25em; margin-top: 40px; border-left: 6px solid #0f172a; font-weight: bold;">推导基础：中间产物学说</h2><br />
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该方程基于一个核心化学反应模型：酶 (E) 与底物 (S) 可逆结合生成复合物 (ES)，ES 再不可逆地分解为产物 (P) 和游离酶 (E)。<br />
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E + S ⇌ ES &rarr; E + P<br />
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<th style="padding: 12px; border: 1px solid #cbd5e1; color: #0f172a; width: 25%;">假设条件</th><br />
<th style="padding: 12px; border: 1px solid #cbd5e1; color: #1e40af; width: 75%;">解释</th><br />
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<td style="padding: 10px; border: 1px solid #cbd5e1; font-weight: 600;">稳态假设<br>(Steady-State)</td><br />
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这是 Briggs & Haldane (1925) 修正后的关键假设：在反应初期，[ES] 复合物的生成速率等于其分解速率，即 <strong>[ES] 浓度保持恒定</strong>。<br />
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<td style="padding: 10px; border: 1px solid #cbd5e1; font-weight: 600;">初速度条件<br>(Initial Rate)</td><br />
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仅测量反应刚开始时的速率 ($v_0$)。此时产物 [P] 极少，可以忽略逆反应 (P &rarr; S)。<br />
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<td style="padding: 10px; border: 1px solid #cbd5e1; font-weight: 600;">底物过量</td><br />
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[S] &gt;&gt; [E]<sub>total</sub>，确保酶被底物包围，总底物浓度约等于游离底物浓度。<br />
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<h2 style="background: #f1f5f9; color: #0f172a; padding: 10px 18px; border-radius: 0 6px 6px 0; font-size: 1.25em; margin-top: 40px; border-left: 6px solid #0f172a; font-weight: bold;">米氏常数 (K<sub>m</sub>) 的物理意义</h2><br />
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K<sub>m</sub> 是酶的一个特征常数，它不随酶浓度的改变而改变，只取决于酶的种类、底物类型和环境条件（pH、温度）。<br />
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<li style="margin-bottom: 12px;"><strong>亲和力的度量：</strong> K<sub>m</sub> 值越<strong>小</strong>，表示酶与底物的亲和力越<strong>强</strong>（只需要很少的底物就能达到半饱和）。反之，K<sub>m</sub> 大则亲和力弱。</li><br />
<li style="margin-bottom: 12px;"><strong>生理调节：</strong> <br />
<br>• <strong>[[己糖激酶]] (Hexokinase)：</strong> K<sub>m</sub> 极低 (~0.05 mM)，确保脑细胞在低血糖时也能摄取葡萄糖。<br />
<br>• <strong>[[葡萄糖激酶]] (Glucokinase)：</strong> K<sub>m</sub> 较高 (~5 mM)，只在餐后高血糖时才在肝脏全速工作，储存糖原。</li><br />
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<span style="color: #0f172a; font-weight: bold; font-size: 1.05em; display: inline-block; margin-bottom: 15px;">学术参考文献 [Academic Review]</span><br />
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[1] <strong>Michaelis L, Menten ML. (1913).</strong> <em>Die Kinetik der Invertinwirkung.</em> <strong>[[Biochemische Zeitschrift]]</strong>. <br><br />
<span style="color: #475569;">[点评]：历史性文献。虽然原文用德语发表且基于“快速平衡假设”，但它定义了酶动力学的基本范式。</span><br />
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[2] <strong>Briggs GE, Haldane JB. (1925).</strong> <em>A note on the kinetics of enzyme action.</em> <strong>[[Biochemical Journal]]</strong>. <br><br />
<span style="color: #475569;">[点评]：对米氏方程进行了极其重要的修正，引入了“稳态假设”，使方程具有了更广泛的普适性，即我们今天教科书上使用的版本。</span><br />
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[3] <strong>Johnson KA, Goody RS. (2011).</strong> <em>The original Michaelis constant: translation of the 1913 Michaelis-Menten paper.</em> <strong>[[Biochemistry]]</strong>. <br><br />
<span style="color: #475569;">[点评]：为了纪念米氏方程 100 周年，提供了原文的英文翻译和现代视角的深度评论。</span><br />
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<div style="background-color: #eff6ff; color: #1e40af; padding: 8px 15px; font-weight: bold; text-align: center; border-bottom: 1px solid #dbeafe;"><br />
动力学理论体系 · 知识图谱<br />
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<td style="width: 85px; background-color: #f8fafc; color: #334155; font-weight: 600; padding: 10px 12px; text-align: right; vertical-align: middle;">上级学科</td><br />
<td style="padding: 10px 15px; color: #334155;">[[酶动力学]] • 物理化学</td><br />
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<td style="width: 85px; background-color: #f8fafc; color: #334155; font-weight: 600; padding: 10px 12px; text-align: right; vertical-align: middle;">线性化工具</td><br />
<td style="padding: 10px 15px; color: #334155;">[[Lineweaver-Burk]] (双倒数) • Eadie-Hofstee</td><br />
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<td style="width: 85px; background-color: #f8fafc; color: #334155; font-weight: 600; padding: 10px 12px; text-align: right; vertical-align: middle;">例外情况</td><br />
<td style="padding: 10px 15px; color: #334155;">[[别构调节]] (Sigmoidal曲线) • 抑制剂存在</td><br />
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