https://www.yiliao.com/index.php?action=history&feed=atom&title=%E6%A8%A1%E6%9D%BF%3APBB%2F7157 2026-04-29T01:15:32Z 本wiki的该页面的版本历史 MediaWiki 1.35.1 https://www.yiliao.com/index.php?title=%E6%A8%A1%E6%9D%BF:PBB/7157&diff=299914&oldid=prev 2015-09-16T02:46:05Z

<p>以“{{GNF_Protein_box | Name = 肿瘤蛋白p53 | image = p53.png | image_source = <a href="/index.php?title=%E8%9B%8B%E7%99%BD%E8%B4%A8%E6%95%B0%E6%8D%AE%E5%BA%93&amp;action=edit&amp;redlink=1" class="new" title="蛋白质数据库（页面不存在）">PDB</a>基于{{PDBe|1TUP}}的渲染：P53与DNA结合&lt;ref&gt;{{cite ...”为内容创建页面</p> <p><b>新页面</b></p><div>{{GNF_Protein_box<br /> | Name = 肿瘤蛋白p53<br /> | image = p53.png<br /> | image_source = [[蛋白质数据库|PDB]]基于{{PDBe|1TUP}}的渲染：P53与DNA结合&lt;ref&gt;{{cite pmid|8023157}}&lt;/ref&gt;<br /> | PDB = {{PDB2|1A1U}}、 {{PDB2|1AIE}}、 {{PDB2|1C26}}、 {{PDB2|1DT7}}、 {{PDB2|1GZH}}、 {{PDB2|1H26}}、 {{PDB2|1HS5}}、 {{PDB2|1JSP}}、 {{PDB2|1KZY}}、 {{PDB2|1MA3}}、 {{PDB2|1OLG}}、 {{PDB2|1OLH}}、 {{PDB2|1PES}}、 {{PDB2|1PET}}、 {{PDB2|1SAE}}、 {{PDB2|1SAF}}、 {{PDB2|1SAK}}、 {{PDB2|1SAL}}、 {{PDB2|1TSR}}、 {{PDB2|1TUP}}、 {{PDB2|1UOL}}、 {{PDB2|1XQH}}、 {{PDB2|1YC5}}、 {{PDB2|1YCQ}}、 {{PDB2|1YCR}}、 {{PDB2|1YCS}}、 {{PDB2|2AC0}}、 {{PDB2|2ADY}}、 {{PDB2|2AHI}}、 {{PDB2|2ATA}}、 {{PDB2|2B3G}}、 {{PDB2|2BIM}}、 {{PDB2|2BIN}}、 {{PDB2|2BIO}}、 {{PDB2|2BIP}}、 {{PDB2|2BIQ}}、 {{PDB2|2FEJ}}、 {{PDB2|2FOJ}}、 {{PDB2|2FOO}}、 {{PDB2|2GS0}}、 {{PDB2|2H1L}}、 {{PDB2|2H2D}}、 {{PDB2|2H2F}}、 {{PDB2|2H4F}}、 {{PDB2|2H4H}}、 {{PDB2|2H4J}}、 {{PDB2|2H59}}、 {{PDB2|2J0Z}}、 {{PDB2|2J10}}、 {{PDB2|2J11}}、 {{PDB2|2J1W}}、 {{PDB2|2J1X}}、 {{PDB2|2J1Y}}、 {{PDB2|2J1Z}}、 {{PDB2|2J20}}、 {{PDB2|2J21}}、 {{PDB2|2K8F}}、 {{PDB2|2L14}}、 {{PDB2|2LY4}}、 {{PDB2|2OCJ}}、 {{PDB2|2PCX}}、 {{PDB2|2QVQ}}、 {{PDB2|2QXA}}、 {{PDB2|2QXB}}、 {{PDB2|2QXC}}、 {{PDB2|2VUK}}、 {{PDB2|2WGX}}、 {{PDB2|2X0U}}、 {{PDB2|2X0V}}、 {{PDB2|2X0W}}、 {{PDB2|2XWR}}、 {{PDB2|2YBG}}、 {{PDB2|2Z5S}}、 {{PDB2|2Z5T}}、 {{PDB2|3D05}}、 {{PDB2|3D06}}、 {{PDB2|3D07}}、 {{PDB2|3D08}}、 {{PDB2|3D09}}、 {{PDB2|3D0A}}、 {{PDB2|3DAB}}、 {{PDB2|3DAC}}、 {{PDB2|3IGK}}、 {{PDB2|3IGL}}、 {{PDB2|3KMD}}、 {{PDB2|3KZ8}}、 {{PDB2|3LW1}}、 {{PDB2|3PDH}}、 {{PDB2|3Q01}}、 {{PDB2|3Q05}}、 {{PDB2|3Q06}}、 {{PDB2|3SAK}}、 {{PDB2|3TG5}}、 {{PDB2|3TS8}}、 {{PDB2|4AGL}}、 {{PDB2|4AGM}}、 {{PDB2|4AGN}}、 {{PDB2|4AGO}}、 {{PDB2|4AGP}}、 {{PDB2|4AGQ}}<br /> | HGNCid = 11998<br /> | MGIid = 98834<br /> | Symbol = TP53<br /> | AltSymbols =; BCC7; LFS1; P53; TRP53<br /> | IUPHAR = <br /> | ChEMBL = 4096<br /> | OMIM = 191170<br /> | ECnumber = <br /> | Homologene = 460<br /> | GeneAtlas_image1 = PBB GE TP53 201746 at.png<br /> | GeneAtlas_image2 = PBB GE TP53 211300 s at.png<br /> | GeneAtlas_image3 = <br /> | Protein_domain_image = <br /> | Function = {{GNF_GO|id=GO:0001077 |text = RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription}} {{GNF_GO|id=GO:0001085 |text = RNA polymerase II transcription factor binding}} {{GNF_GO|id=GO:0001228 |text = RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription}} {{GNF_GO|id=GO:0002020 |text = protease binding}} {{GNF_GO|id=GO:0002039 |text = p53 binding}} {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003682 |text = chromatin binding}} {{GNF_GO|id=GO:0003684 |text = damaged DNA binding}} {{GNF_GO|id=GO:0003700 |text = sequence-specific DNA binding transcription factor activity}} {{GNF_GO|id=GO:0005507 |text = copper ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008134 |text = transcription factor binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0019899 |text = enzyme binding}} {{GNF_GO|id=GO:0019901 |text = protein kinase binding}} {{GNF_GO|id=GO:0030971 |text = receptor tyrosine kinase binding}} {{GNF_GO|id=GO:0031625 |text = ubiquitin protein ligase binding}} {{GNF_GO|id=GO:0035033 |text = histone deacetylase regulator activity}} {{GNF_GO|id=GO:0035035 |text = histone acetyltransferase binding}} {{GNF_GO|id=GO:0042802 |text = identical protein binding}} {{GNF_GO|id=GO:0044212 |text = transcription regulatory region DNA binding}} {{GNF_GO|id=GO:0046982 |text = protein heterodimerization activity}} {{GNF_GO|id=GO:0047485 |text = protein N-terminus binding}} {{GNF_GO|id=GO:0051087 |text = chaperone binding}} {{GNF_GO|id=GO:0051721 |text = protein phosphatase 2A binding}}<br /> | Component = {{GNF_GO|id=GO:0000785 |text = chromatin}} {{GNF_GO|id=GO:0000790 |text = nuclear chromatin}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005654 |text = nucleoplasm}} {{GNF_GO|id=GO:0005657 |text = replication fork}} {{GNF_GO|id=GO:0005669 |text = transcription factor TFIID complex}} {{GNF_GO|id=GO:0005678 |text = chromatin assembly complex}} {{GNF_GO|id=GO:0005730 |text = nucleolus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005739 |text = mitochondrion}} {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005829 |text = cytosol}} {{GNF_GO|id=GO:0016363 |text = nuclear matrix}} {{GNF_GO|id=GO:0016604 |text = nuclear body}} {{GNF_GO|id=GO:0016605 |text = PML body}} {{GNF_GO|id=GO:0043234 |text = protein complex}}<br /> | Process = {{GNF_GO|id=GO:0000060 |text = protein import into nucleus、 translocation}} {{GNF_GO|id=GO:0000075 |text = cell cycle checkpoint}} {{GNF_GO|id=GO:0000122 |text = negative regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0000733 |text = DNA strand renaturation}} {{GNF_GO|id=GO:0001701 |text = in utero embryonic development}} {{GNF_GO|id=GO:0001756 |text = somitogenesis}} {{GNF_GO|id=GO:0001836 |text = release of cytochrome c from mitochondria}} {{GNF_GO|id=GO:0002309 |text = T cell proliferation involved in immune response}} {{GNF_GO|id=GO:0002326 |text = B cell lineage commitment}} {{GNF_GO|id=GO:0002360 |text = T cell lineage commitment}} {{GNF_GO|id=GO:0006284 |text = base-excision repair}} {{GNF_GO|id=GO:0006289 |text = nucleotide-excision repair}} {{GNF_GO|id=GO:0006302 |text = double-strand break repair}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription、 DNA-dependent}} {{GNF_GO|id=GO:0006461 |text = protein complex assembly}} {{GNF_GO|id=GO:0006915 |text = apoptotic process}} {{GNF_GO|id=GO:0006917 |text = induction of apoptosis}} {{GNF_GO|id=GO:0006974 |text = response to DNA damage stimulus}} {{GNF_GO|id=GO:0006977 |text = DNA damage response、 signal transduction by p53 class mediator resulting in cell cycle arrest}} {{GNF_GO|id=GO:0006978 |text = DNA damage response、 signal transduction by p53 class mediator resulting in transcription of p21 class mediator}} {{GNF_GO|id=GO:0006983 |text = ER overload response}} {{GNF_GO|id=GO:0007050 |text = cell cycle arrest}} {{GNF_GO|id=GO:0007179 |text = transforming growth factor beta receptor signaling pathway}} {{GNF_GO|id=GO:0007265 |text = Ras protein signal transduction}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007369 |text = gastrulation}} {{GNF_GO|id=GO:0007406 |text = negative regulation of neuroblast proliferation}} {{GNF_GO|id=GO:0007417 |text = central nervous system development}} {{GNF_GO|id=GO:0007569 |text = cell aging}} {{GNF_GO|id=GO:0007596 |text = blood coagulation}} {{GNF_GO|id=GO:0008104 |text = protein localization}} {{GNF_GO|id=GO:0008156 |text = negative regulation of DNA replication}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}} {{GNF_GO|id=GO:0008340 |text = determination of adult lifespan}} {{GNF_GO|id=GO:0009303 |text = rRNA transcription}} {{GNF_GO|id=GO:0009651 |text = response to salt stress}} {{GNF_GO|id=GO:0010165 |text = response to X-ray}} {{GNF_GO|id=GO:0010332 |text = response to gamma radiation}} {{GNF_GO|id=GO:0019048 |text = virus-host interaction}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}} {{GNF_GO|id=GO:0030308 |text = negative regulation of cell growth}} {{GNF_GO|id=GO:0030330 |text = DNA damage response、 signal transduction by p53 class mediator}} {{GNF_GO|id=GO:0030512 |text = negative regulation of transforming growth factor beta receptor signaling pathway}} {{GNF_GO|id=GO:0031065 |text = positive regulation of histone deacetylation}} {{GNF_GO|id=GO:0031571 |text = mitotic cell cycle G1/S transition DNA damage checkpoint}} {{GNF_GO|id=GO:0032461 |text = positive regulation of protein oligomerization}} {{GNF_GO|id=GO:0033077 |text = T cell differentiation in thymus}} {{GNF_GO|id=GO:0034613 |text = cellular protein localization}} {{GNF_GO|id=GO:0034644 |text = cellular response to UV}} {{GNF_GO|id=GO:0035264 |text = multicellular organism growth}} {{GNF_GO|id=GO:0035690 |text = cellular response to drug}} {{GNF_GO|id=GO:0042149 |text = cellular response to glucose starvation}} {{GNF_GO|id=GO:0042771 |text = intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator}} {{GNF_GO|id=GO:0042981 |text = regulation of apoptotic process}} {{GNF_GO|id=GO:0043065 |text = positive regulation of apoptotic process}} {{GNF_GO|id=GO:0043066 |text = negative regulation of apoptotic process}} {{GNF_GO|id=GO:0043525 |text = positive regulation of neuron apoptotic process}} {{GNF_GO|id=GO:0045892 |text = negative regulation of transcription、 DNA-dependent}} {{GNF_GO|id=GO:0045893 |text = positive regulation of transcription、 DNA-dependent}} {{GNF_GO|id=GO:0045944 |text = positive regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0046677 |text = response to antibiotic}} {{GNF_GO|id=GO:0046902 |text = regulation of mitochondrial membrane permeability}} {{GNF_GO|id=GO:0048147 |text = negative regulation of fibroblast proliferation}} {{GNF_GO|id=GO:0050731 |text = positive regulation of peptidyl-tyrosine phosphorylation}} {{GNF_GO|id=GO:0051097 |text = negative regulation of helicase activity}} {{GNF_GO|id=GO:0051262 |text = protein tetramerization}} {{GNF_GO|id=GO:0051276 |text = chromosome organization}} {{GNF_GO|id=GO:0051402 |text = neuron apoptotic process}} {{GNF_GO|id=GO:0070245 |text = positive regulation of thymocyte apoptotic process}} {{GNF_GO|id=GO:0071158 |text = positive regulation of cell cycle arrest}} {{GNF_GO|id=GO:0071456 |text = cellular response to hypoxia}} {{GNF_GO|id=GO:0071479 |text = cellular response to ionizing radiation}} {{GNF_GO|id=GO:0071850 |text = mitotic cell cycle arrest}} {{GNF_GO|id=GO:0072332 |text = intrinsic apoptotic signaling pathway by p53 class mediator}} {{GNF_GO|id=GO:0090200 |text = positive regulation of release of cytochrome c from mitochondria}} {{GNF_GO|id=GO:0090343 |text = positive regulation of cell aging}} {{GNF_GO|id=GO:0090399 |text = replicative senescence}} {{GNF_GO|id=GO:0090403 |text = oxidative stress-induced premature senescence}} {{GNF_GO|id=GO:0097193 |text = intrinsic apoptotic signaling pathway}} {{GNF_GO|id=GO:2000379 |text = positive regulation of reactive oxygen species metabolic process}} {{GNF_GO|id=GO:2001244 |text = positive regulation of intrinsic apoptotic signaling pathway}}<br /> | Hs_EntrezGene = 7157<br /> | Hs_Ensembl = ENSG00000141510<br /> | Hs_RefseqmRNA = NM_000546.5<br /> | Hs_RefseqProtein = NP_000537.3<br /> | Hs_GenLoc_db = hg19<br /> | Hs_GenLoc_chr = 17<br /> | Hs_GenLoc_start = 7565097<br /> | Hs_GenLoc_end = 7590856<br /> | Hs_Uniprot = P04637<br /> | Mm_EntrezGene = 22059<br /> | Mm_Ensembl = ENSMUSG00000059552<br /> | Mm_RefseqmRNA = NM_001127233.1<br /> | Mm_RefseqProtein = NP_001120705.1<br /> | Mm_GenLoc_db = mm9<br /> | Mm_GenLoc_chr = 11<br /> | Mm_GenLoc_start = 69580359<br /> | Mm_GenLoc_end = 69591873<br /> | Mm_Uniprot = P02340<br /> | path = PBB/7157<br /> }}&lt;noinclude&gt;<br /> {{reflist}}<br /> &lt;/noinclude&gt;</div>

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