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小细胞肺癌免疫治疗 (SCLC Immunotherapy) - 版本历史
2026-04-03T22:01:46Z
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2025年12月31日 (三) 22:23 77921020
2025-12-31T22:23:30Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">←上一版本</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">2025年12月31日 (三) 22:23的版本</td>
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<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <div style="margin: 40px 0; border: <del class="diffchange diffchange-inline">1.2px </del>solid #<del class="diffchange diffchange-inline">cbd5e1</del>; border-radius: 8px; overflow: hidden; font-family: 'Helvetica Neue', Arial, sans-serif; font-size: 0.9em;"></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <div style="margin: 40px 0; border: <ins class="diffchange diffchange-inline">1px </ins>solid #<ins class="diffchange diffchange-inline">e2e8f0</ins>; border-radius: 8px; overflow: hidden; font-family: 'Helvetica Neue', Arial, sans-serif; font-size: 0.9em;"></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <div style="background-color: #<del class="diffchange diffchange-inline">0f172a</del>; color: #<del class="diffchange diffchange-inline">ffffff</del>; padding: <del class="diffchange diffchange-inline">10px </del>15px; font-weight: bold; <del class="diffchange diffchange-inline">letter</del>-<del class="diffchange diffchange-inline">spacing</del>: <del class="diffchange diffchange-inline">1px</del>; <del class="diffchange diffchange-inline">text</del>-<del class="diffchange diffchange-inline">align</del>: <del class="diffchange diffchange-inline">center</del>;"></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <div style="background-color: #<ins class="diffchange diffchange-inline">eff6ff</ins>; color: #<ins class="diffchange diffchange-inline">1e40af</ins>; padding: <ins class="diffchange diffchange-inline">8px </ins>15px; font-weight: bold; <ins class="diffchange diffchange-inline">text</ins>-<ins class="diffchange diffchange-inline">align</ins>: <ins class="diffchange diffchange-inline">center</ins>; <ins class="diffchange diffchange-inline">border</ins>-<ins class="diffchange diffchange-inline">bottom</ins>: <ins class="diffchange diffchange-inline">1px solid #dbeafe</ins>;"></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> SCLC 免疫治疗 · <del class="diffchange diffchange-inline">结构化知识图谱</del></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> SCLC 免疫治疗 · <ins class="diffchange diffchange-inline">知识图谱</ins></div></td></tr>
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<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"> </del></div></td><td colspan="2"> </td></tr>
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<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <tr style="border-bottom: 1px solid #<del class="diffchange diffchange-inline">e2e8f0</del>;"></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <tr style="border-bottom: 1px solid #<ins class="diffchange diffchange-inline">f1f5f9</ins>;"></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <td style="width: <del class="diffchange diffchange-inline">100px</del>; background-color: #f8fafc; color: #<del class="diffchange diffchange-inline">1e40af</del>; font-weight: <del class="diffchange diffchange-inline">700</del>; padding: 12px <del class="diffchange diffchange-inline">15px</del>; text-align: right; vertical-align: <del class="diffchange diffchange-inline">top</del>; white-space: nowrap;"></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <td style="width: <ins class="diffchange diffchange-inline">85px</ins>; background-color: #f8fafc; color: #<ins class="diffchange diffchange-inline">334155</ins>; font-weight: <ins class="diffchange diffchange-inline">600</ins>; padding: <ins class="diffchange diffchange-inline">10px </ins>12px; text-align: right; vertical-align: <ins class="diffchange diffchange-inline">middle</ins>; white-space: nowrap;">核心药物</td></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline"> </del>核心药物</div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: <ins class="diffchange diffchange-inline">10px </ins>15px; color: #334155;">[[阿替利珠单抗]] • [[度伐利尤单抗]] • [[Tarlatamab]] • [[依托泊苷]]</td></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline"> </del></td></div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: <del class="diffchange diffchange-inline">12px </del>15px; color: #334155<del class="diffchange diffchange-inline">; line-height: 1.6</del>;"></div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline"> </del>[[阿替利珠单抗]] • [[度伐利尤单抗]] • [[Tarlatamab]] <del class="diffchange diffchange-inline">(BiTE) </del>• [[依托泊苷]] <del class="diffchange diffchange-inline">• [[Lurbinectedin]]</del></div></td><td colspan="2"> </td></tr>
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<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </tr></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <tr style="border-bottom: 1px solid #<ins class="diffchange diffchange-inline">f1f5f9</ins>;"></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <tr style="border-bottom: 1px solid #<del class="diffchange diffchange-inline">e2e8f0</del>;"></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <td style="width: <ins class="diffchange diffchange-inline">85px</ins>; background-color: #f8fafc; color: #<ins class="diffchange diffchange-inline">334155</ins>; font-weight: <ins class="diffchange diffchange-inline">600</ins>; padding: <ins class="diffchange diffchange-inline">10px </ins>12px; text-align: right; vertical-align: <ins class="diffchange diffchange-inline">middle</ins>; white-space: nowrap;">关键靶点</td></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <td style="width: <del class="diffchange diffchange-inline">100px</del>; background-color: #f8fafc; color: #<del class="diffchange diffchange-inline">1e40af</del>; font-weight: <del class="diffchange diffchange-inline">700</del>; padding: 12px <del class="diffchange diffchange-inline">15px</del>; text-align: right; vertical-align: <del class="diffchange diffchange-inline">top</del>; white-space: nowrap;"></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: <ins class="diffchange diffchange-inline">10px </ins>15px; color: #334155;">[[DLL3]] • [[PD-L1]] • [[TIGIT]] • [[CD47]] • [[LAG-3]] • [[PARP]]</td></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline"> </del>关键靶点</div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline"> </del></td></div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: <del class="diffchange diffchange-inline">12px </del>15px; color: #334155<del class="diffchange diffchange-inline">; line-height: 1.6</del>;"></div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline"> </del>[[DLL3]] • [[PD-L1]] • [[TIGIT]] • [[CD47]] • [[LAG-3]] • [[PARP]]</div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline"> </del></td></div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </tr></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <tr style="border-bottom: 1px solid #<ins class="diffchange diffchange-inline">f1f5f9</ins>;"></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <tr style="border-bottom: 1px solid #<del class="diffchange diffchange-inline">e2e8f0</del>;"></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <td style="width: <ins class="diffchange diffchange-inline">85px</ins>; background-color: #f8fafc; color: #<ins class="diffchange diffchange-inline">334155</ins>; font-weight: <ins class="diffchange diffchange-inline">600</ins>; padding: <ins class="diffchange diffchange-inline">10px </ins>12px; text-align: right; vertical-align: <ins class="diffchange diffchange-inline">middle</ins>; white-space: nowrap;">机制概念</td></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <td style="width: <del class="diffchange diffchange-inline">100px</del>; background-color: #f8fafc; color: #<del class="diffchange diffchange-inline">1e40af</del>; font-weight: <del class="diffchange diffchange-inline">700</del>; padding: 12px <del class="diffchange diffchange-inline">15px</del>; text-align: right; vertical-align: <del class="diffchange diffchange-inline">top</del>; white-space: nowrap;"></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: <ins class="diffchange diffchange-inline">10px </ins>15px; color: #334155;">[[冷肿瘤]] • [[MHC-I下调]] • [[STING通路]] • [[副肿瘤综合征]]</td></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline"> </del>机制概念</div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline"> </del></td></div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: <del class="diffchange diffchange-inline">12px </del>15px; color: #334155<del class="diffchange diffchange-inline">; line-height: 1.6</del>;"></div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline"> </del>[[冷肿瘤]] • [[MHC-I下调]] • [[STING通路]] • [[副肿瘤综合征]] <del class="diffchange diffchange-inline">• [[免疫逃逸]]</del></div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline"> </del></td></div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </tr></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"></del></div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <td style="width: <del class="diffchange diffchange-inline">100px</del>; background-color: #f8fafc; color: #<del class="diffchange diffchange-inline">1e40af</del>; font-weight: <del class="diffchange diffchange-inline">700</del>; padding: 12px <del class="diffchange diffchange-inline">15px</del>; text-align: right; vertical-align: <del class="diffchange diffchange-inline">top</del>; white-space: nowrap;"></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <td style="width: <ins class="diffchange diffchange-inline">85px</ins>; background-color: #f8fafc; color: #<ins class="diffchange diffchange-inline">334155</ins>; font-weight: <ins class="diffchange diffchange-inline">600</ins>; padding: <ins class="diffchange diffchange-inline">10px </ins>12px; text-align: right; vertical-align: <ins class="diffchange diffchange-inline">middle</ins>; white-space: nowrap;">经典研究</td></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline"> </del>经典研究</div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: <ins class="diffchange diffchange-inline">10px </ins>15px; color: #334155;">[[IMpower133]] (罗氏) • [[CASPIAN]] (阿斯利康) • [[DeLLphi-301]]</td></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline"> </del></td></div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: <del class="diffchange diffchange-inline">12px </del>15px; color: #334155<del class="diffchange diffchange-inline">; line-height: 1.6</del>;"></div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline"> </del>[[IMpower133]] (罗氏) • [[CASPIAN]] (阿斯利康) • [[DeLLphi-301]] <del class="diffchange diffchange-inline">(安进)</del></div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline"> </del></td></div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </tr></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </table></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </table></div></td></tr>
</table>
77921020
https://www.yiliao.com/index.php?title=%E5%B0%8F%E7%BB%86%E8%83%9E%E8%82%BA%E7%99%8C%E5%85%8D%E7%96%AB%E6%B2%BB%E7%96%97_(SCLC_Immunotherapy)&diff=312259&oldid=prev
2025年12月31日 (三) 22:21 77921020
2025-12-31T22:21:24Z
<p></p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">←上一版本</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">2025年12月31日 (三) 22:21的版本</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l143" >第143行：</td>
<td colspan="2" class="diff-lineno">第143行：</td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </div></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </div></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <div style="margin: 40px 0; border: 1.<del class="diffchange diffchange-inline">5px </del>solid #<del class="diffchange diffchange-inline">0f172a</del>; border-radius: 8px; overflow: hidden<del class="diffchange diffchange-inline">; font-size: 0.95em</del>; font-family: 'Helvetica Neue', Arial, sans-serif;"></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <div style="margin: 40px 0; border: 1.<ins class="diffchange diffchange-inline">2px </ins>solid #<ins class="diffchange diffchange-inline">cbd5e1</ins>; border-radius: 8px; overflow: hidden; font-family: 'Helvetica Neue', Arial, sans-serif<ins class="diffchange diffchange-inline">; font-size: 0.9em</ins>;"></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <div style="background-color: #0f172a; color: #ffffff; <del class="diffchange diffchange-inline">text-align</del>: <del class="diffchange diffchange-inline">center</del>; font-weight: bold<del class="diffchange diffchange-inline">; padding: 10px</del>; letter-spacing: 1px;">SCLC 免疫治疗 · 结构化知识图谱</div></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <div style="background-color: #0f172a; color: #ffffff; <ins class="diffchange diffchange-inline">padding</ins>: <ins class="diffchange diffchange-inline">10px 15px</ins>; font-weight: bold; letter-spacing: 1px<ins class="diffchange diffchange-inline">; text-align: center</ins>;"></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> </ins>SCLC 免疫治疗 · 结构化知识图谱</div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> </ins></div></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <<del class="diffchange diffchange-inline">div </del>style="background: #ffffff<del class="diffchange diffchange-inline">; padding: 5px 20px</del>;"></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <<ins class="diffchange diffchange-inline">table </ins>style="<ins class="diffchange diffchange-inline">width: 100%; border-collapse: collapse; </ins>background<ins class="diffchange diffchange-inline">-color</ins>: #ffffff;"></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <<del class="diffchange diffchange-inline">div </del>style="<del class="diffchange diffchange-inline">padding: 12px 0; </del>border-bottom: 1px <del class="diffchange diffchange-inline">dashed </del>#<del class="diffchange diffchange-inline">cbd5e1; display: flex; align-items: baseline</del>;"></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <<ins class="diffchange diffchange-inline">tr </ins>style="border-bottom: 1px <ins class="diffchange diffchange-inline">solid </ins>#<ins class="diffchange diffchange-inline">e2e8f0</ins>;"></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <<del class="diffchange diffchange-inline">span </del>style="color: #1e40af; font-weight: 700; <del class="diffchange diffchange-inline">width</del>: <del class="diffchange diffchange-inline">85px</del>; <del class="diffchange diffchange-inline">flex</del>-<del class="diffchange diffchange-inline">shrink</del>: <del class="diffchange diffchange-inline">0</del>;"><del class="diffchange diffchange-inline">核心药物：</del></<del class="diffchange diffchange-inline">span</del>></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <<ins class="diffchange diffchange-inline">td </ins>style="<ins class="diffchange diffchange-inline">width: 100px; background-color: #f8fafc; </ins>color: #1e40af; font-weight: 700; <ins class="diffchange diffchange-inline">padding: 12px 15px; text-align: right; vertical-align</ins>: <ins class="diffchange diffchange-inline">top</ins>; <ins class="diffchange diffchange-inline">white</ins>-<ins class="diffchange diffchange-inline">space</ins>: <ins class="diffchange diffchange-inline">nowrap</ins>;"></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <<del class="diffchange diffchange-inline">span </del>style="color: #334155; line-height: 1.6;"></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> 核心药物</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> </ins></<ins class="diffchange diffchange-inline">td</ins>></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <<ins class="diffchange diffchange-inline">td </ins>style="<ins class="diffchange diffchange-inline">padding: 12px 15px; </ins>color: #334155; line-height: 1.6;"></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> [[阿替利珠单抗]] • [[度伐利尤单抗]] • [[Tarlatamab]] (BiTE) • [[依托泊苷]] • [[Lurbinectedin]]</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> [[阿替利珠单抗]] • [[度伐利尤单抗]] • [[Tarlatamab]] (BiTE) • [[依托泊苷]] • [[Lurbinectedin]]</div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </<del class="diffchange diffchange-inline">span</del>></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </<ins class="diffchange diffchange-inline">td</ins>></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </<del class="diffchange diffchange-inline">div</del>></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </<ins class="diffchange diffchange-inline">tr</ins>></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <<del class="diffchange diffchange-inline">div </del>style="<del class="diffchange diffchange-inline">padding: 12px 0; </del>border-bottom: 1px <del class="diffchange diffchange-inline">dashed </del>#<del class="diffchange diffchange-inline">cbd5e1; display: flex; align-items: baseline</del>;"></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <<ins class="diffchange diffchange-inline">tr </ins>style="border-bottom: 1px <ins class="diffchange diffchange-inline">solid </ins>#<ins class="diffchange diffchange-inline">e2e8f0</ins>;"></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <<del class="diffchange diffchange-inline">span </del>style="color: #1e40af; font-weight: 700; <del class="diffchange diffchange-inline">width</del>: <del class="diffchange diffchange-inline">85px</del>; <del class="diffchange diffchange-inline">flex</del>-<del class="diffchange diffchange-inline">shrink</del>: <del class="diffchange diffchange-inline">0</del>;"><del class="diffchange diffchange-inline">关键靶点：</del></<del class="diffchange diffchange-inline">span</del>></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <<ins class="diffchange diffchange-inline">td </ins>style="<ins class="diffchange diffchange-inline">width: 100px; background-color: #f8fafc; </ins>color: #1e40af; font-weight: 700; <ins class="diffchange diffchange-inline">padding: 12px 15px; text-align: right; vertical-align</ins>: <ins class="diffchange diffchange-inline">top</ins>; <ins class="diffchange diffchange-inline">white</ins>-<ins class="diffchange diffchange-inline">space</ins>: <ins class="diffchange diffchange-inline">nowrap</ins>;"></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <<del class="diffchange diffchange-inline">span </del>style="color: #334155; line-height: 1.6;"></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> 关键靶点</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> </ins></<ins class="diffchange diffchange-inline">td</ins>></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <<ins class="diffchange diffchange-inline">td </ins>style="<ins class="diffchange diffchange-inline">padding: 12px 15px; </ins>color: #334155; line-height: 1.6;"></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> [[DLL3]] • [[PD-L1]] • [[TIGIT]] • [[CD47]] • [[LAG-3]] • [[PARP]]</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> [[DLL3]] • [[PD-L1]] • [[TIGIT]] • [[CD47]] • [[LAG-3]] • [[PARP]]</div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </<del class="diffchange diffchange-inline">span</del>></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </<ins class="diffchange diffchange-inline">td</ins>></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </<del class="diffchange diffchange-inline">div</del>></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </<ins class="diffchange diffchange-inline">tr</ins>></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <<del class="diffchange diffchange-inline">div </del>style="<del class="diffchange diffchange-inline">padding: 12px 0; </del>border-bottom: 1px <del class="diffchange diffchange-inline">dashed </del>#<del class="diffchange diffchange-inline">cbd5e1; display: flex; align-items: baseline</del>;"></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <<ins class="diffchange diffchange-inline">tr </ins>style="border-bottom: 1px <ins class="diffchange diffchange-inline">solid </ins>#<ins class="diffchange diffchange-inline">e2e8f0</ins>;"></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <<del class="diffchange diffchange-inline">span </del>style="color: #1e40af; font-weight: 700; <del class="diffchange diffchange-inline">width</del>: <del class="diffchange diffchange-inline">85px</del>; <del class="diffchange diffchange-inline">flex</del>-<del class="diffchange diffchange-inline">shrink</del>: <del class="diffchange diffchange-inline">0</del>;"><del class="diffchange diffchange-inline">机制概念：</del></<del class="diffchange diffchange-inline">span</del>></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <<ins class="diffchange diffchange-inline">td </ins>style="<ins class="diffchange diffchange-inline">width: 100px; background-color: #f8fafc; </ins>color: #1e40af; font-weight: 700; <ins class="diffchange diffchange-inline">padding: 12px 15px; text-align: right; vertical-align</ins>: <ins class="diffchange diffchange-inline">top</ins>; <ins class="diffchange diffchange-inline">white</ins>-<ins class="diffchange diffchange-inline">space</ins>: <ins class="diffchange diffchange-inline">nowrap</ins>;"></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <<del class="diffchange diffchange-inline">span </del>style="color: #334155; line-height: 1.6;"></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> 机制概念</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> </ins></<ins class="diffchange diffchange-inline">td</ins>></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <<ins class="diffchange diffchange-inline">td </ins>style="<ins class="diffchange diffchange-inline">padding: 12px 15px; </ins>color: #334155; line-height: 1.6;"></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> [[冷肿瘤]] • [[MHC-I下调]] • [[STING通路]] • [[副肿瘤综合征]] • [[免疫逃逸]]</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> [[冷肿瘤]] • [[MHC-I下调]] • [[STING通路]] • [[副肿瘤综合征]] • [[免疫逃逸]]</div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </<del class="diffchange diffchange-inline">span</del>></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </<ins class="diffchange diffchange-inline">td</ins>></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </<del class="diffchange diffchange-inline">div</del>></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </<ins class="diffchange diffchange-inline">tr</ins>></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <<del class="diffchange diffchange-inline">div </del>style="<del class="diffchange diffchange-inline">padding</del>: <del class="diffchange diffchange-inline">12px 0</del>; <del class="diffchange diffchange-inline">display: flex; align</del>-<del class="diffchange diffchange-inline">items</del>: <del class="diffchange diffchange-inline">baseline</del>;<del class="diffchange diffchange-inline">"></del></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <<ins class="diffchange diffchange-inline">tr></ins></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline"> <span style="</del>color: #1e40af; font-weight: 700; <del class="diffchange diffchange-inline">width</del>: <del class="diffchange diffchange-inline">85px</del>; <del class="diffchange diffchange-inline">flex</del>-<del class="diffchange diffchange-inline">shrink</del>: <del class="diffchange diffchange-inline">0</del>;"><del class="diffchange diffchange-inline">经典研究：</del></<del class="diffchange diffchange-inline">span</del>></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> <td </ins>style="<ins class="diffchange diffchange-inline">width</ins>: <ins class="diffchange diffchange-inline">100px</ins>; <ins class="diffchange diffchange-inline">background</ins>-<ins class="diffchange diffchange-inline">color</ins>: <ins class="diffchange diffchange-inline">#f8fafc</ins>; color: #1e40af; font-weight: 700; <ins class="diffchange diffchange-inline">padding: 12px 15px; text-align: right; vertical-align</ins>: <ins class="diffchange diffchange-inline">top</ins>; <ins class="diffchange diffchange-inline">white</ins>-<ins class="diffchange diffchange-inline">space</ins>: <ins class="diffchange diffchange-inline">nowrap</ins>;"></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <<del class="diffchange diffchange-inline">span </del>style="color: #334155; line-height: 1.6;"></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> 经典研究</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> </ins></<ins class="diffchange diffchange-inline">td</ins>></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <<ins class="diffchange diffchange-inline">td </ins>style="<ins class="diffchange diffchange-inline">padding: 12px 15px; </ins>color: #334155; line-height: 1.6;"></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> [[IMpower133]] (罗氏) • [[CASPIAN]] (阿斯利康) • [[DeLLphi-301]] (安进)</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> [[IMpower133]] (罗氏) • [[CASPIAN]] (阿斯利康) • [[DeLLphi-301]] (安进)</div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </<del class="diffchange diffchange-inline">span</del>></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </<ins class="diffchange diffchange-inline">td</ins>></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </<del class="diffchange diffchange-inline">div</del>></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </<ins class="diffchange diffchange-inline">tr</ins>></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </<del class="diffchange diffchange-inline">div</del>></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </<ins class="diffchange diffchange-inline">table</ins>></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </div></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </div></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div></div></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div></div></div></td></tr>
</table>
77921020
https://www.yiliao.com/index.php?title=%E5%B0%8F%E7%BB%86%E8%83%9E%E8%82%BA%E7%99%8C%E5%85%8D%E7%96%AB%E6%B2%BB%E7%96%97_(SCLC_Immunotherapy)&diff=312258&oldid=prev
2025年12月31日 (三) 22:18 77921020
2025-12-31T22:18:19Z
<p></p>
<table class="diff diff-contentalign-left diff-editfont-monospace" data-mw="interface">
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">←上一版本</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">2025年12月31日 (三) 22:18的版本</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l143" >第143行：</td>
<td colspan="2" class="diff-lineno">第143行：</td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </div></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </div></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <div style="margin: 40px 0; border: 1.5px solid #0f172a; border-radius: 8px; overflow: hidden; font-size: 0.95em;"></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <div style="margin: 40px 0; border: 1.5px solid #0f172a; border-radius: 8px; overflow: hidden; font-size: 0.95em<ins class="diffchange diffchange-inline">; font-family: 'Helvetica Neue', Arial, sans-serif</ins>;"></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <div style="background-color: #0f172a; color: #ffffff; text-align: center; font-weight: bold; padding: 10px; letter-spacing: 1px;"><del class="diffchange diffchange-inline">SCLC免疫治疗 </del>· <del class="diffchange diffchange-inline">知识图谱关联</del></div></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <div style="background-color: #0f172a; color: #ffffff; text-align: center; font-weight: bold; padding: 10px; letter-spacing: 1px;"><ins class="diffchange diffchange-inline">SCLC 免疫治疗 </ins>· <ins class="diffchange diffchange-inline">结构化知识图谱</ins></div></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <div style="padding: <del class="diffchange diffchange-inline">15px</del>; <del class="diffchange diffchange-inline">background</del>: #<del class="diffchange diffchange-inline">ffffff</del>; line-height: <del class="diffchange diffchange-inline">2</del>.<del class="diffchange diffchange-inline">2</del>; <del class="diffchange diffchange-inline">text</del>-align: <del class="diffchange diffchange-inline">center</del>; <del class="diffchange diffchange-inline">text</del>-<del class="diffchange diffchange-inline">decoration</del>: <del class="diffchange diffchange-inline">none</del>;"></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> </ins></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline"> </del>[[DLL3]] • [[<del class="diffchange diffchange-inline">Tarlatamab</del>]] • [[<del class="diffchange diffchange-inline">阿替利珠单抗</del>]] • [[<del class="diffchange diffchange-inline">IMpower133</del>]] • [[<del class="diffchange diffchange-inline">CASPIAN</del>]] • [[<del class="diffchange diffchange-inline">PARP抑制剂</del>]] <del class="diffchange diffchange-inline">• </del>[[冷肿瘤]] • [[MHC-I下调]] • [[<del class="diffchange diffchange-inline">STING</del>]] • [[<del class="diffchange diffchange-inline">TIGIT</del>]]</div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <div style="<ins class="diffchange diffchange-inline">background: #ffffff; </ins>padding: <ins class="diffchange diffchange-inline">5px 20px</ins>;<ins class="diffchange diffchange-inline">"></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> <div style="padding: 12px 0; border-bottom: 1px dashed #cbd5e1; display: flex; align-items: baseline;"></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> <span style="color: #1e40af; font-weight: 700; width: 85px; flex-shrink: 0;">核心药物：</span></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> <span style="color</ins>: #<ins class="diffchange diffchange-inline">334155</ins>; line-height: <ins class="diffchange diffchange-inline">1</ins>.<ins class="diffchange diffchange-inline">6;"></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> [[阿替利珠单抗]] • [[度伐利尤单抗]] • [[Tarlatamab]] (BiTE) • [[依托泊苷]] • [[Lurbinectedin]]</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> </span></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> </div></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> <div style="padding: 12px 0</ins>; <ins class="diffchange diffchange-inline">border</ins>-<ins class="diffchange diffchange-inline">bottom: 1px dashed #cbd5e1; display: flex; </ins>align<ins class="diffchange diffchange-inline">-items</ins>: <ins class="diffchange diffchange-inline">baseline;"></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> <span style="color: #1e40af; font-weight: 700; width: 85px; flex-shrink: 0;">关键靶点：</span></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> <span style="color: #334155</ins>; <ins class="diffchange diffchange-inline">line</ins>-<ins class="diffchange diffchange-inline">height</ins>: <ins class="diffchange diffchange-inline">1.6</ins>;"></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> </ins>[[DLL3]] • [[<ins class="diffchange diffchange-inline">PD-L1</ins>]] • [[<ins class="diffchange diffchange-inline">TIGIT</ins>]] • [[<ins class="diffchange diffchange-inline">CD47</ins>]] • [[<ins class="diffchange diffchange-inline">LAG-3</ins>]] • [[<ins class="diffchange diffchange-inline">PARP</ins>]]</div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> </span></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> </div></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> <div style="padding: 12px 0; border-bottom: 1px dashed #cbd5e1; display: flex; align-items: baseline;"></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> <span style="color: #1e40af; font-weight: 700; width: 85px; flex-shrink: 0;">机制概念：</span></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> <span style="color: #334155; line-height: 1.6;"></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> </ins>[[冷肿瘤]] • [[MHC-I下调]] • [[<ins class="diffchange diffchange-inline">STING通路]] • [[副肿瘤综合征]] • [[免疫逃逸]]</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> </span></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> </div></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> <div style="padding: 12px 0; display: flex; align-items: baseline;"></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> <span style="color: #1e40af; font-weight: 700; width: 85px; flex-shrink: 0;">经典研究：</span></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> <span style="color: #334155; line-height: 1.6;"></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> [[IMpower133]] (罗氏) • [[CASPIAN</ins>]] <ins class="diffchange diffchange-inline">(阿斯利康) </ins>• [[<ins class="diffchange diffchange-inline">DeLLphi-301</ins>]] <ins class="diffchange diffchange-inline">(安进)</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> </span></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> </div></ins></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </div></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </div></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </div></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </div></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div></div></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div></div></div></td></tr>
</table>
77921020
https://www.yiliao.com/index.php?title=%E5%B0%8F%E7%BB%86%E8%83%9E%E8%82%BA%E7%99%8C%E5%85%8D%E7%96%AB%E6%B2%BB%E7%96%97_(SCLC_Immunotherapy)&diff=312257&oldid=prev
77921020：建立内容为“<div style="padding: 0 4%; line-height: 1.8; color: #1e293b; font-family: 'Helvetica Neue', Helvetica, 'PingFang SC', Arial, sans-serif; background-color: #ffffff…”的新页面
2025-12-31T22:11:46Z
<p>建立内容为“<div style="padding: 0 4%; line-height: 1.8; color: #1e293b; font-family: 'Helvetica Neue', Helvetica, 'PingFang SC', Arial, sans-serif; background-color: #ffffff…”的新页面</p>
<p><b>新页面</b></p><div><div style="padding: 0 4%; line-height: 1.8; color: #1e293b; font-family: 'Helvetica Neue', Helvetica, 'PingFang SC', Arial, sans-serif; background-color: #ffffff; max-width: 1200px; margin: auto;"><br />
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<div style="margin-bottom: 30px; border-bottom: 1.2px solid #e2e8f0; padding-bottom: 25px;"><br />
<p style="font-size: 1.1em; margin: 10px 0; color: #334155; text-align: justify;"><br />
<strong>小细胞肺癌免疫治疗</strong>（Immunotherapy for SCLC）代表了该疾病治疗史上继铂类化疗之后的第二次革命。长期以来，SCLC 因其“免疫冷肿瘤”特性（低 MHC 表达、少淋巴细胞浸润）被视为免疫治疗的禁区。然而，基于 <strong>IMpower133</strong> 和 <strong>CASPIAN</strong> 两项里程碑式研究，<strong>[[PD-L1抑制剂]]</strong>（阿替利珠单抗、度伐利尤单抗）联合化疗已成为广泛期 SCLC 的全球标准一线方案，成功打破了 30 年来总生存期（OS）无法突破 10 个月的僵局。目前，SCLC 免疫治疗的发展方向正从单纯的检查点抑制，向靶向 <strong>[[DLL3]]</strong> 的双特异性抗体（如 <strong>[[Tarlatamab]]</strong>）、抗体偶联药物 (ADC) 以及联合 <strong>[[PARP抑制剂]]</strong> 等新型组合策略纵深发展。<br />
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<div class="medical-infobox mw-collapsible mw-collapsed" style="width: 100%; max-width: 320px; margin: 0 auto 35px auto; border: 1.2px solid #bae6fd; border-radius: 12px; background-color: #ffffff; box-shadow: 0 8px 20px rgba(0,0,0,0.05); overflow: hidden;"><br />
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<div style="padding: 15px; color: #1e40af; background: linear-gradient(135deg, #e0f2fe 0%, #bae6fd 100%); text-align: center; cursor: pointer;"><br />
<div style="font-size: 1.2em; font-weight: bold; letter-spacing: 1.2px;">SCLC 免疫治疗</div><br />
<div style="font-size: 0.7em; opacity: 0.85; margin-top: 4px; white-space: nowrap;">Current Standard & Future Horizon (点击展开)</div><br />
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<div class="mw-collapsible-content"><br />
<div style="padding: 25px; text-align: center; background-color: #f8fafc;"><br />
<div style="display: inline-block; background: #ffffff; border: 1px solid #e2e8f0; border-radius: 12px; padding: 20px; box-shadow: 0 4px 10px rgba(0,0,0,0.04);"><br />
[[Image:SCLC_immune_microenvironment.png|100px|SCLC 免疫微环境示意图]]<br />
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<div style="font-size: 0.8em; color: #64748b; margin-top: 12px; font-weight: 600;">冷肿瘤突围 / DLL3 靶向</div><br />
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<table style="width: 100%; border-spacing: 0; border-collapse: collapse; font-size: 0.85em;"><br />
<tr><br />
<th style="text-align: left; padding: 6px 12px; background-color: #f1f5f9; color: #475569; border-bottom: 1px solid #e2e8f0; width: 40%;">一线标准 (1L)</th><br />
<td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #0f172a;">化疗 (EP) + <strong>[[PD-L1抑制剂]]</strong></td><br />
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<tr><br />
<th style="text-align: left; padding: 6px 12px; background-color: #f1f5f9; color: #475569; border-bottom: 1px solid #e2e8f0;">关键药物</th><br />
<td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #1e40af;">[[阿替利珠单抗]] (Tecentriq)<br>[[度伐利尤单抗]] (Imfinzi)</td><br />
</tr><br />
<tr><br />
<th style="text-align: left; padding: 6px 12px; background-color: #f1f5f9; color: #475569; border-bottom: 1px solid #e2e8f0;">二线/三线突破</th><br />
<td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #b91c1c;"><strong>[[Tarlatamab]]</strong> (DLL3/CD3 BiTE)</td><br />
</tr><br />
<tr><br />
<th style="text-align: left; padding: 6px 12px; background-color: #f1f5f9; color: #475569; border-bottom: 1px solid #e2e8f0;">获益亚型</th><br />
<td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #0f172a;">SCLC-I (Inflamed type)</td><br />
</tr><br />
<tr><br />
<th style="text-align: left; padding: 6px 12px; background-color: #f1f5f9; color: #475569; border-bottom: 1px solid #e2e8f0;">主要障碍</th><br />
<td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #0f172a;">MHC-I 下调, 缺乏 TILs</td><br />
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<tr><br />
<th style="text-align: left; padding: 6px 12px; background-color: #f1f5f9; color: #475569; border-bottom: 1px solid #e2e8f0;">未来靶点</th><br />
<td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #0f172a;">[[DLL3]], [[TIGIT]], [[CD47]], [[LAG-3]]</td><br />
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<tr><br />
<th style="text-align: left; padding: 6px 12px; background-color: #f1f5f9; color: #475569;">联合策略</th><br />
<td style="padding: 6px 12px; color: #0f172a;">+ PARP抑制剂, + 抗血管生成</td><br />
</tr><br />
</table><br />
</div><br />
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<h2 style="background: #f1f5f9; color: #0f172a; padding: 10px 18px; border-radius: 0 6px 6px 0; font-size: 1.25em; margin-top: 40px; border-left: 6px solid #0f172a; font-weight: bold;">历史地位：从“免疫荒漠”到“长尾效应”</h2><br />
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SCLC 免疫治疗的成功并非一蹴而就，它经历了一个从失望到希望的过程。<br />
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<th style="padding: 12px; border: 1px solid #cbd5e1; color: #0f172a; width: 30%;">研究阶段</th><br />
<th style="padding: 12px; border: 1px solid #cbd5e1; color: #475569;">核心发现</th><br />
<th style="padding: 12px; border: 1px solid #cbd5e1; color: #1e40af;">临床启示</th><br />
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<td style="padding: 10px; border: 1px solid #cbd5e1; font-weight: 600;">早期探索 (PD-1 单药)</td><br />
<td style="padding: 10px; border: 1px solid #cbd5e1;">CheckMate-032 / KEYNOTE-028</td><br />
<td style="padding: 10px; border: 1px solid #cbd5e1;">纳武利尤单抗和帕博利珠单抗在后线治疗中 ORR 仅为 10-20%，且未能显著改善 OS。这揭示了 SCLC <strong>“冷肿瘤”</strong>的本质。</td><br />
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<td style="padding: 10px; border: 1px solid #cbd5e1; font-weight: 600;"><strong>一线突破 (化疗联合)</strong></td><br />
<td style="padding: 10px; border: 1px solid #cbd5e1;"><strong>IMpower133</strong> (阿替利珠单抗)<br><strong>CASPIAN</strong> (度伐利尤单抗)</td><br />
<td style="padding: 10px; border: 1px solid #cbd5e1;">两项研究均证实，化疗+PD-L1抑制剂可将 mOS 从 10 个月提升至 12-13 个月。虽然中位提升有限，但关键在于<strong>“长尾效应”</strong>：约 15-20% 的患者实现了长期生存（>3年），这在化疗时代是不可想象的。</td><br />
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<h2 style="background: #f1f5f9; color: #0f172a; padding: 10px 18px; border-radius: 0 6px 6px 0; font-size: 1.25em; margin-top: 40px; border-left: 6px solid #0f172a; font-weight: bold;">生物学困境：高 TMB 为何低应答？</h2><br />
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SCLC 拥有所有实体瘤中最高的肿瘤突变负荷 (TMB)，理论上应产生大量新抗原而被免疫系统识别。然而，SCLC 进化出了极强的免疫逃逸机制：<br />
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<li style="margin-bottom: 12px;"><strong>MHC-I 类分子下调：</strong><br />
<br>SCLC 细胞通过表观遗传沉默 MHC-I 类分子表达，使得 T 细胞无法“看见”肿瘤抗原。</li><br />
<li style="margin-bottom: 12px;"><strong>神经内分泌特性：</strong><br />
<br>作为神经内分泌肿瘤，SCLC 天生缺乏共刺激分子，且肿瘤微环境 (TME) 中充斥着抑制性的骨髓来源抑制细胞 (MDSCs) 和 M2 型巨噬细胞，缺乏 CD8+ T 细胞浸润（即<strong>“免疫沙漠”</strong>）。</li><br />
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<h2 style="background: #f1f5f9; color: #0f172a; padding: 10px 18px; border-radius: 0 6px 6px 0; font-size: 1.25em; margin-top: 40px; border-left: 6px solid #0f172a; font-weight: bold;">未来方向：从“被动防御”到“主动出击”</h2><br />
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鉴于单纯 PD-1/L1 抑制剂的瓶颈，SCLC 的免疫治疗正转向<strong>靶向特定表面抗原</strong>的主动攻击策略。<br />
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<h3 style="margin-top: 0; color: #1e40af; font-size: 1.1em;">🔥 热点突破：双特异性抗体 (BiTEs)</h3><br />
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<strong>DLL3 (Delta-like ligand 3)</strong> 是目前 SCLC 最受瞩目的靶点。它在 >80% 的 SCLC 表面高表达，但在正常组织极少表达。<br />
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<li style="margin-bottom: 8px;"><strong>[[Tarlatamab]]：</strong> 一端结合肿瘤表面的 DLL3，另一端结合 T 细胞表面的 CD3。这种“拉郎配”机制<strong>强行将 T 细胞拉向肿瘤</strong>并激活，无需 MHC 分子呈递，直接克服了 SCLC 的 MHC 下调逃逸机制。</li><br />
<li style="margin-bottom: 0;"><strong>DeLLphi-301 研究：</strong> Tarlatamab 在多线治疗失败的 SCLC 患者中显示出前所未有的疗效，已获 FDA 加速批准。</li><br />
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[[Image:Tarlatamab_mechanism_DLL3_CD3_BiTE.png|100px|Tarlatamab 作用机制]]<br />
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<h3 style="color: #334155; border-bottom: 1px solid #e2e8f0; padding-bottom: 8px; margin-top: 30px;">其他前沿策略</h3><br />
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<li style="margin-bottom: 12px;"><strong>DNA 损伤修复 (DDR) 联合：</strong><br />
<br>SCLC 存在复制压力。<strong>[[PARP抑制剂]]</strong>（如奥拉帕利）可诱导 DNA 双链断裂，激活 <strong>[[cGAS-STING]]</strong> 通路，增加细胞质 DNA 水平，从而招募 T 细胞，将冷肿瘤变热，增敏 PD-L1 抑制剂。</li><br />
<li style="margin-bottom: 12px;"><strong>“别吃我”信号阻断：</strong><br />
<br>靶向 <strong>[[CD47]]</strong> 的抗体（如 Magrolimab）旨在恢复巨噬细胞对 SCLC 的吞噬作用。</li><br />
<li style="margin-bottom: 12px;"><strong>新型检查点：</strong><br />
<br>靶向 <strong>[[TIGIT]]</strong> (Tiragolumab) 或 <strong>[[LAG-3]]</strong> 的药物正在与 PD-L1 抑制剂联用，试图在多维度解除免疫抑制。Skyscraper-02 研究虽未达预期，但探索仍在继续。</li><br />
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<span style="color: #0f172a; font-weight: bold; font-size: 1.05em; display: inline-block; margin-bottom: 15px;">学术参考文献与权威点评</span><br />
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[1] <strong>Horn L, et al. (2018).</strong> <em>First-Line Atezolizumab plus Chemotherapy in Extensive-Stage Small-Cell Lung Cancer.</em> <strong>[[New England Journal of Medicine]] (NEJM)</strong>. <br><br />
<span style="color: #475569;">[学术点评]：破冰之作。IMpower133 研究，确立了免疫联合化疗作为 ES-SCLC 标准一线治疗的地位，是该领域 30 年来的首个重大生存获益。</span><br />
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[2] <strong>Paz-Ares L, et al. (2019).</strong> <em>Durvalumab plus platinum-etoposide versus platinum-etoposide in first-line treatment of extensive-stage small-cell lung cancer (CASPIAN): a randomised, controlled, open-label, phase 3 trial.</em> <strong>[[The Lancet]]</strong>. <br><br />
<span style="color: #475569;">[学术点评]：疗效验证。CASPIAN 研究不仅证实了度伐利尤单抗的疗效，还显示了长期生存获益（3年 OS 率约为化疗组的 3 倍），强化了免疫治疗的长尾效应。</span><br />
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[3] <strong>Ahn MJ, et al. (2023).</strong> <em>Tarlatamab for Patients with Previously Treated Small-Cell Lung Cancer.</em> <strong>[[New England Journal of Medicine]] (NEJM)</strong>. <br><br />
<span style="color: #475569;">[学术点评]：双抗元年。DeLLphi-301 II期临床结果，靶向 DLL3 的 BiTE 药物 Tarlatamab 在后线难治性 SCLC 中展现出惊人的疗效和持久性，开启了非检查点免疫治疗的新时代。</span><br />
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[4] <strong>Gay CM, et al. (2021).</strong> <em>Patterns of transcription factor programs and immune pathway activation define four distinct subtypes of small cell lung cancer.</em> <strong>[[Cancer Cell]]</strong>. <br><br />
<span style="color: #475569;">[学术点评]：亚型指导。明确了 SCLC-I（炎症型）亚型对免疫治疗最为敏感，为未来的生物标志物筛选和精准免疫治疗指明了方向。</span><br />
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<div style="background-color: #0f172a; color: #ffffff; text-align: center; font-weight: bold; padding: 10px; letter-spacing: 1px;">SCLC免疫治疗 · 知识图谱关联</div><br />
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[[DLL3]] • [[Tarlatamab]] • [[阿替利珠单抗]] • [[IMpower133]] • [[CASPIAN]] • [[PARP抑制剂]] • [[冷肿瘤]] • [[MHC-I下调]] • [[STING]] • [[TIGIT]]<br />
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