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大细胞神经内分泌癌 - 版本历史
2026-04-09T11:49:00Z
本wiki的该页面的版本历史
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2026年1月27日 (二) 06:46 77921020
2026-01-27T06:46:18Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">←上一版本</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">2026年1月27日 (二) 06:46的版本</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l12" >第12行：</td>
<td colspan="2" class="diff-lineno">第12行：</td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <div style="background: linear-gradient(135deg, #eff6ff 0%, #dbeafe 100%); padding: 12px; text-align: center; border-bottom: 1px solid #bfdbfe;"></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <div style="background: linear-gradient(135deg, #eff6ff 0%, #dbeafe 100%); padding: 12px; text-align: center; border-bottom: 1px solid #bfdbfe;"></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <strong style="color: #1e40af; font-size: 18px;">临床数据摘要</strong></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <strong style="color: #1e40af; font-size: 18px;">临床数据摘要</strong></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"> </div></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"> <div style="padding: 15px; text-align: center; background-color: #f8fafc; border-bottom: 1px solid #e2e8f0;"></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"> <div style="display: inline-block; width: 50px; height: 50px; border-radius: 50%; background: #fff1f2; border: 2px solid #e11d48; line-height: 50px; color: #9f1239; font-weight: bold; font-size: 14px;">NE</div></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"> <div style="font-size: 12px; color: #64748b; margin-top: 8px; font-weight: 600;">高侵袭性神经内分泌癌</div></ins></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </div></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </div></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <table style="width: 100%; border-collapse: collapse; font-size: 14px;"></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <table style="width: 100%; border-collapse: collapse; font-size: 14px;"></div></td></tr>
<tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l23" >第23行：</td>
<td colspan="2" class="diff-lineno">第27行：</td></tr>
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<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: 10px 15px; background-color: #f8fafc; color: #64748b; border-bottom: 1px solid #e2e8f0; vertical-align: top;"><del class="diffchange diffchange-inline">关键标记</del></td></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: 10px 15px; background-color: #f8fafc; color: #64748b; border-bottom: 1px solid #e2e8f0; vertical-align: top;"><ins class="diffchange diffchange-inline">IHC 标记</ins></td></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: 10px 15px; color: #1e40af; border-bottom: 1px solid #e2e8f0; vertical-align: top;"><strong>[[CD56]]</strong>, CgA, Syn</td></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: 10px 15px; color: #1e40af; border-bottom: 1px solid #e2e8f0; vertical-align: top;"><strong>[[CD56]]</strong>, CgA, Syn</td></div></td></tr>
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<tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l32" >第32行：</td>
<td colspan="2" class="diff-lineno">第36行：</td></tr>
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<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: 10px 15px; background-color: #f8fafc; color: #64748b; border-bottom: 1px solid #e2e8f0; vertical-align: top;">恶性程度</td></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: 10px 15px; background-color: #f8fafc; color: #64748b; border-bottom: 1px solid #e2e8f0; vertical-align: top;">恶性程度</td></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: 10px 15px; color: #b91c1c; border-bottom: 1px solid #e2e8f0; vertical-align: top;">极高 (<del class="diffchange diffchange-inline">High Grade</del>)</td></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: 10px 15px; color: #b91c1c; border-bottom: 1px solid #e2e8f0; vertical-align: top;">极高 (<ins class="diffchange diffchange-inline">G3级</ins>)</td></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </tr></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr></div></td></tr>
<tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l75" >第75行：</td>
<td colspan="2" class="diff-lineno">第79行：</td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: 15px; vertical-align: top; color: #444; border-right: 1px solid #e2e8f0;"></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: 15px; vertical-align: top; color: #444; border-right: 1px solid #e2e8f0;"></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> • <strong>RB1 野生型</strong> (保留)<br></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> • <strong>RB1 野生型</strong> (保留)<br></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> • 常伴 <strong>KRAS</strong>, STK11, KEAP1 突变<br></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> • 常伴 <strong><ins class="diffchange diffchange-inline">[[</ins>KRAS<ins class="diffchange diffchange-inline">]]</ins></strong>, STK11, KEAP1 突变<br></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> • 基因图谱接近吸烟相关肺腺癌</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> • 基因图谱接近吸烟相关肺腺癌</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </td></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </td></div></td></tr>
<tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l91" >第91行：</td>
<td colspan="2" class="diff-lineno">第95行：</td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <p style="margin-bottom: 20px; color: #555;">2026版指南强调：所有确诊 LCNEC 的患者强烈建议进行 <strong>[[NGS]]</strong> 检测，以区分分子亚型并指导化疗方案的选择。</p></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <p style="margin-bottom: 20px; color: #555;">2026版指南强调：所有确诊 LCNEC 的患者强烈建议进行 <strong>[[NGS]]</strong> 检测，以区分分子亚型并指导化疗方案的选择。</p></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <div style="overflow-x: auto; border: 1px solid #bfdbfe; border-radius: 6px;"></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <div style="overflow-x: auto; border: 1px solid #bfdbfe; border-radius: 6px<ins class="diffchange diffchange-inline">; margin-bottom: 40px</ins>;"></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <table style="width: 100%; min-width: 600px; border-collapse: collapse; text-align: left;"></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <table style="width: 100%; min-width: 600px; border-collapse: collapse; text-align: left;"></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr style="background-color: #eff6ff; border-bottom: 2px solid #60a5fa; color: #1e40af;"></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr style="background-color: #eff6ff; border-bottom: 2px solid #60a5fa; color: #1e40af;"></div></td></tr>
<tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l144" >第144行：</td>
<td colspan="2" class="diff-lineno">第148行：</td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </li></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </li></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <li style="margin-bottom: 8px;"></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <li style="margin-bottom: 8px;"></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <strong>Derks JL, et al.</strong> Clinical outcomes of emerging therapeutic targets in large cell neuroendocrine carcinoma. <em>Journal of Thoracic Oncology</em>, <del class="diffchange diffchange-inline">2024</del>. (临床回顾性研究，证实了分型治疗的获益)</div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <strong>Derks JL, et al.</strong> Clinical outcomes of emerging therapeutic targets in large cell neuroendocrine carcinoma. <em>Journal of Thoracic Oncology</em>, <ins class="diffchange diffchange-inline">2018</ins>. (临床回顾性研究，证实了分型治疗的获益)</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </li></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </li></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <li style="margin-bottom: 8px;"></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <li style="margin-bottom: 8px;"></div></td></tr>
<tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l155" >第155行：</td>
<td colspan="2" class="diff-lineno">第159行：</td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </div></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </div></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <div style="margin-top: <del class="diffchange diffchange-inline">30px</del>; background-color: #<del class="diffchange diffchange-inline">f1f5f9</del>; <del class="diffchange diffchange-inline">padding</del>: <del class="diffchange diffchange-inline">15px</del>; text-align: <del class="diffchange diffchange-inline">center</del>; border-<del class="diffchange diffchange-inline">radius</del>: <del class="diffchange diffchange-inline">6px</del>; font-<del class="diffchange diffchange-inline">size</del>: <del class="diffchange diffchange-inline">14px</del>; color: #<del class="diffchange diffchange-inline">475569</del>;"></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <div style="margin-top: <ins class="diffchange diffchange-inline">50px</ins>; <ins class="diffchange diffchange-inline">border: 1px solid #bae6fd; border-radius: 8px; overflow: hidden; font-family: 'Helvetica Neue', Arial, sans-serif; font-size: 14px; box-shadow: 0 4px 6px -1px rgba(0,0,0,0.05);"></ins></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline"> </del><strong><del class="diffchange diffchange-inline">知识图谱：</del></strong></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> </ins></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline"> </del>[[<del class="diffchange diffchange-inline">非小细胞肺癌</del>]] <del class="diffchange diffchange-inline">&middot</del>; [[小细胞肺癌]] <del class="diffchange diffchange-inline">&middot</del>; [[TP53]] <del class="diffchange diffchange-inline">&middot; </del>[[RB1]] <del class="diffchange diffchange-inline">&middot</del>; [[依托泊苷]] <del class="diffchange diffchange-inline">&middot</del>; [[<del class="diffchange diffchange-inline">神经内分泌肿瘤</del>]]</div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> <div style="</ins>background<ins class="diffchange diffchange-inline">: linear-gradient(135deg, #eff6ff 0%, #dbeafe 100%); padding: 12px 20px; border</ins>-<ins class="diffchange diffchange-inline">bottom: 2px solid #3b82f6; display: flex; justify-content: space-between; align-items: center;"></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> <div style="</ins>color: #<ins class="diffchange diffchange-inline">1e40af; font-weight: bold; font-size: 16px;"></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> <span style="margin-right: 8px;">🕸️</span> 肺癌诊疗 · 知识图谱</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> </div></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> <div style="font-size: 12px; color: #60a5fa;">Thoracic Oncology Knowledge Graph</div></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> </div></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> <table style="width: 100%; border-collapse: collapse</ins>; <ins class="diffchange diffchange-inline">background-color</ins>: <ins class="diffchange diffchange-inline">#ffffff</ins>; text-align: <ins class="diffchange diffchange-inline">left</ins>;<ins class="diffchange diffchange-inline">"></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> <tr style="</ins>border-<ins class="diffchange diffchange-inline">bottom: 1px solid #f1f5f9;"></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> <td style="width: 110px; background-color: #f8fafc; color</ins>: <ins class="diffchange diffchange-inline">#475569</ins>; font-<ins class="diffchange diffchange-inline">weight: 600; padding: 12px 15px; border-right: 1px solid #f1f5f9; vertical-align: middle;"></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> 疾病谱系</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> </td></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> <td style="padding</ins>: <ins class="diffchange diffchange-inline">12px 20px</ins>; color: #<ins class="diffchange diffchange-inline">334155; line-height: 1.6</ins>;"></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> </ins><strong><ins class="diffchange diffchange-inline">[[非小细胞肺癌]]</ins></strong<ins class="diffchange diffchange-inline">> (NSCLC) <span style="color:#cbd5e1; margin:0 6px;">|</span</ins>> </div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> [[肺腺癌]] <span style="color:#cbd5e1; margin:0 6px;">|</span> </ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> </ins>[[<ins class="diffchange diffchange-inline">肺鳞癌</ins>]] <ins class="diffchange diffchange-inline"><span style="color:#cbd5e1</ins>; <ins class="diffchange diffchange-inline">margin:0 6px;">|</span> </ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> [[大细胞肺癌]] <span style="color:#cbd5e1; margin:0 6px;">|</span> </ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> <strong></ins>[[小细胞肺癌]]<ins class="diffchange diffchange-inline"></strong> (SCLC) <span style="color:#cbd5e1</ins>; <ins class="diffchange diffchange-inline">margin:0 6px;">|</span> </ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> [[LCNEC]]</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> </td></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> </tr></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> </ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> <tr style="border-bottom: 1px solid #f1f5f9;"></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> <td style="width: 110px; background-color: #f8fafc; color: #475569; font-weight: 600; padding: 12px 15px; border-right: 1px solid #f1f5f9; vertical-align: middle;"></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> 分子靶点</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> </td></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> <td style="padding: 12px 20px; color: #334155; line-height: 1.6;"></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> <span style="background:#f0fdf4; color:#166534; padding:2px 6px; border-radius:4px; font-size:12px;">常见</span> </ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> [[EGFR]] • [[ALK]] • [[KRAS]] </ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> <span style="display:inline-block; width:10px;"></span></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> <span style="background:#fffbeb; color:#b45309; padding:2px 6px; border-radius:4px; font-size:12px;">罕见</span> </ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> </ins>[[TP53]] <ins class="diffchange diffchange-inline">• </ins>[[RB1]] <ins class="diffchange diffchange-inline">• [[STK11]] • [[DLL3]]</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> </td></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> </tr></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> <tr style="border-bottom: 1px solid #f1f5f9</ins>;<ins class="diffchange diffchange-inline">"></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> <td style="width: 110px; background-color: #f8fafc; color: #475569; font-weight: 600; padding: 12px 15px; border-right: 1px solid #f1f5f9; vertical-align: middle;"></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> 核心药物</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> </td></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> <td style="padding: 12px 20px; color: #334155; line-height: 1.6;"></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> <strong>化疗：</strong> </ins>[[依托泊苷]] <ins class="diffchange diffchange-inline">• [[顺铂]] • [[紫杉醇]] • [[吉西他滨]]<br></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> <strong>免疫：</strong> [[帕博利珠单抗]] (K药) • [[阿替利珠单抗]] (T药)</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> </td></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> </tr></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> <tr></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> <td style="width: 110px; background-color: #f8fafc; color: #475569; font-weight: 600; padding: 12px 15px</ins>; <ins class="diffchange diffchange-inline">border-right: 1px solid #f1f5f9; vertical-align: middle;"></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> 诊疗前沿</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> </td></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> <td style="padding: 12px 20px; color: #334155; line-height: 1.6;"></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> </ins>[[<ins class="diffchange diffchange-inline">NGS分型</ins>]] <ins class="diffchange diffchange-inline">• [[DLL3]] • [[神经内分泌转化]] • [[副肿瘤综合征]]</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> </td></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> </tr></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> </table></ins></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </div></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </div></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div></div></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div></div></div></td></tr>
</table>
77921020
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77921020：建立内容为“<div style="font-family: 'Helvetica Neue', Helvetica, 'PingFang SC', 'Microsoft YaHei', Arial, sans-serif; font-size: 16px; line-height: 1.6; color: #333; backgro…”的新页面
2026-01-27T06:40:14Z
<p>建立内容为“<div style="font-family: 'Helvetica Neue', Helvetica, 'PingFang SC', 'Microsoft YaHei', Arial, sans-serif; font-size: 16px; line-height: 1.6; color: #333; backgro…”的新页面</p>
<p><b>新页面</b></p><div><div style="font-family: 'Helvetica Neue', Helvetica, 'PingFang SC', 'Microsoft YaHei', Arial, sans-serif; font-size: 16px; line-height: 1.6; color: #333; background-color: #fff; max-width: 1200px; margin: 0 auto; padding: 20px;"><br />
<br />
<div style="border-bottom: 3px solid #1e40af; padding-bottom: 20px; margin-bottom: 30px;"><br />
<h1 style="color: #1e40af; font-size: 28px; margin: 0 0 10px 0;">大细胞神经内分泌癌</h1><br />
<div style="color: #666; font-size: 14px; margin-bottom: 15px;">Large Cell Neuroendocrine Carcinoma (LCNEC)</div><br />
<p style="text-align: justify; margin: 0; color: #444;"><br />
<strong>大细胞神经内分泌癌</strong>（LCNEC）是一种罕见且侵袭性极高的肺部恶性肿瘤，虽然在 WHO 分类中被归类为<strong>[[非小细胞肺癌]]</strong>（NSCLC）的一个亚型，但其生物学行为和临床特征更接近<strong>[[小细胞肺癌]]</strong>（SCLC）。LCNEC 具有独特的“嵌合”特性：细胞形态巨大（像 NSCLC），但表达神经内分泌标记物（像 SCLC）。随着 <strong>[[NGS]]</strong> 技术的发展，LCNEC 目前被认为是一组异质性疾病。根据 <strong>NCCN Guidelines (v1.2026)</strong>，治疗策略正从传统的“一刀切”转向基于 <strong>[[TP53]]</strong> 和 <strong>[[RB1]]</strong> 基因状态的精准分层治疗。<br />
</p><br />
</div><br />
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<div style="width: 320px; float: right; margin: 0 0 20px 20px; border: 1px solid #bae6fd; border-radius: 8px; overflow: hidden; box-shadow: 0 4px 10px rgba(0,0,0,0.05); background-color: #fff;"><br />
<div style="background: linear-gradient(135deg, #eff6ff 0%, #dbeafe 100%); padding: 12px; text-align: center; border-bottom: 1px solid #bfdbfe;"><br />
<strong style="color: #1e40af; font-size: 18px;">临床数据摘要</strong><br />
</div><br />
<table style="width: 100%; border-collapse: collapse; font-size: 14px;"><br />
<tr><br />
<td style="padding: 10px 15px; background-color: #f8fafc; color: #64748b; border-bottom: 1px solid #e2e8f0; width: 40%; vertical-align: top;">ICD-10</td><br />
<td style="padding: 10px 15px; color: #333; border-bottom: 1px solid #e2e8f0; vertical-align: top;">C34</td><br />
</tr><br />
<tr><br />
<td style="padding: 10px 15px; background-color: #f8fafc; color: #64748b; border-bottom: 1px solid #e2e8f0; vertical-align: top;">发病率</td><br />
<td style="padding: 10px 15px; color: #333; border-bottom: 1px solid #e2e8f0; vertical-align: top;">约 3% (罕见)</td><br />
</tr><br />
<tr><br />
<td style="padding: 10px 15px; background-color: #f8fafc; color: #64748b; border-bottom: 1px solid #e2e8f0; vertical-align: top;">关键标记</td><br />
<td style="padding: 10px 15px; color: #1e40af; border-bottom: 1px solid #e2e8f0; vertical-align: top;"><strong>[[CD56]]</strong>, CgA, Syn</td><br />
</tr><br />
<tr><br />
<td style="padding: 10px 15px; background-color: #f8fafc; color: #64748b; border-bottom: 1px solid #e2e8f0; vertical-align: top;">核心基因</td><br />
<td style="padding: 10px 15px; color: #b91c1c; border-bottom: 1px solid #e2e8f0; vertical-align: top;">TP53, RB1, KRAS</td><br />
</tr><br />
<tr><br />
<td style="padding: 10px 15px; background-color: #f8fafc; color: #64748b; border-bottom: 1px solid #e2e8f0; vertical-align: top;">恶性程度</td><br />
<td style="padding: 10px 15px; color: #b91c1c; border-bottom: 1px solid #e2e8f0; vertical-align: top;">极高 (High Grade)</td><br />
</tr><br />
<tr><br />
<td style="padding: 10px 15px; background-color: #f8fafc; color: #64748b; vertical-align: top;">主要诱因</td><br />
<td style="padding: 10px 15px; color: #333; vertical-align: top;">重度吸烟</td><br />
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</table><br />
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<h2 style="clear: left; border-left: 5px solid #1e40af; padding-left: 15px; color: #1e40af; margin-top: 40px; margin-bottom: 20px;">分子分型：重新定义疾病</h2><br />
<p style="margin-bottom: 20px; color: #555;">传统的形态学诊断已不足以指导治疗。基于 2016 年 Rekhtman 等人的开创性研究，LCNEC 在基因层面被分为两大类，这直接决定了患者对化疗药物的敏感性。</p><br />
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<div style="overflow-x: auto; border: 1px solid #bfdbfe; border-radius: 6px; margin-bottom: 40px;"><br />
<table style="width: 100%; min-width: 600px; border-collapse: collapse; text-align: left;"><br />
<tr style="background-color: #eff6ff; color: #1e40af;"><br />
<th style="padding: 12px 15px; width: 20%; border-bottom: 2px solid #60a5fa; border-right: 1px solid #bfdbfe; white-space: nowrap;">分子亚型</th><br />
<th style="padding: 12px 15px; width: 40%; border-bottom: 2px solid #60a5fa; border-right: 1px solid #bfdbfe;">基因组特征 (Genomic Profile)</th><br />
<th style="padding: 12px 15px; width: 40%; border-bottom: 2px solid #60a5fa;">临床与治疗相关性</th><br />
</tr><br />
<tr style="border-bottom: 1px solid #e2e8f0;"><br />
<td style="padding: 15px; vertical-align: top; border-right: 1px solid #e2e8f0;"><br />
<strong>SCLC 样型</strong><br><br />
<span style="font-size: 13px; color: #666; margin-top: 4px;">(SCLC-like)</span><br />
</td><br />
<td style="padding: 15px; vertical-align: top; color: #444; border-right: 1px solid #e2e8f0;"><br />
• <strong>RB1 缺失</strong> + TP53 突变<br><br />
• 缺乏 KRAS/STK11 突变<br><br />
• 基因图谱与小细胞肺癌高度重合<br />
</td><br />
<td style="padding: 15px; vertical-align: top; background-color: #fcfdfe;"><br />
<strong style="color: #b91c1c;">对铂类+依托泊苷敏感</strong><br><br />
• 应完全参照 SCLC 方案治疗。<br><br />
• 对紫杉醇/吉西他滨耐药。<br><br />
• 预后相对较差，易发生脑转移。<br />
</td><br />
</tr><br />
<tr style="border-bottom: 1px solid #e2e8f0;"><br />
<td style="padding: 15px; vertical-align: top; border-right: 1px solid #e2e8f0;"><br />
<strong>NSCLC 样型</strong><br><br />
<span style="font-size: 13px; color: #666; margin-top: 4px;">(NSCLC-like)</span><br />
</td><br />
<td style="padding: 15px; vertical-align: top; color: #444; border-right: 1px solid #e2e8f0;"><br />
• <strong>RB1 野生型</strong> (保留)<br><br />
• 常伴 <strong>KRAS</strong>, STK11, KEAP1 突变<br><br />
• 基因图谱接近吸烟相关肺腺癌<br />
</td><br />
<td style="padding: 15px; vertical-align: top;"><br />
<strong style="color: #166534;">对非小细胞化疗方案敏感</strong><br><br />
• 推荐含铂双药（如卡铂+紫杉醇/吉西他滨）。<br><br />
• 对依托泊苷方案反应不佳。<br><br />
• <strong>[[免疫治疗]]</strong> 疗效通常优于 SCLC 样型。<br />
</td><br />
</tr><br />
</table><br />
</div><br />
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<h2 style="border-left: 5px solid #1e40af; padding-left: 15px; color: #1e40af; margin-top: 40px; margin-bottom: 20px;">治疗策略 (NCCN 2026)</h2><br />
<p style="margin-bottom: 20px; color: #555;">2026版指南强调：所有确诊 LCNEC 的患者强烈建议进行 <strong>[[NGS]]</strong> 检测，以区分分子亚型并指导化疗方案的选择。</p><br />
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<div style="overflow-x: auto; border: 1px solid #bfdbfe; border-radius: 6px;"><br />
<table style="width: 100%; min-width: 600px; border-collapse: collapse; text-align: left;"><br />
<tr style="background-color: #eff6ff; border-bottom: 2px solid #60a5fa; color: #1e40af;"><br />
<th style="padding: 12px 15px; width: 15%; border-bottom: 2px solid #60a5fa; border-right: 1px solid #bfdbfe; white-space: nowrap;">临床分期</th><br />
<th style="padding: 12px 15px; width: 25%; border-bottom: 2px solid #60a5fa; border-right: 1px solid #bfdbfe;">治疗目标</th><br />
<th style="padding: 12px 15px; width: 60%; border-bottom: 2px solid #60a5fa;">标准治疗路径</th><br />
</tr><br />
<tr style="border-bottom: 1px solid #e2e8f0;"><br />
<td style="padding: 15px; vertical-align: top; border-right: 1px solid #e2e8f0;"><br />
<strong>早期/可切除</strong><br><br />
<span style="font-size: 13px; color: #666;">(I - IIIA期)</span><br />
</td><br />
<td style="padding: 15px; vertical-align: top; color: #15803d; font-weight: bold; border-right: 1px solid #e2e8f0;"><br />
积极根治<br />
</td><br />
<td style="padding: 15px; vertical-align: top; color: #333;"><br />
1. <strong>首选手术</strong>：解剖性肺叶切除 + 淋巴结清扫。<br><br />
2. <strong>辅助化疗</strong>：无论分期早晚，强烈推荐辅助化疗（复发率极高）。<br><br />
&nbsp;&nbsp;• 方案首选：<strong>[[依托泊苷]] + 铂类</strong> (EP方案)。<br />
</td><br />
</tr><br />
<tr style="border-bottom: 1px solid #e2e8f0;"><br />
<td style="padding: 15px; vertical-align: top; border-right: 1px solid #e2e8f0;"><br />
<strong>晚期/转移性</strong><br><br />
<span style="font-size: 13px; color: #666;">(IV期)</span><br />
</td><br />
<td style="padding: 15px; vertical-align: top; color: #475569; font-weight: bold; border-right: 1px solid #e2e8f0;"><br />
分型精准治疗<br />
</td><br />
<td style="padding: 15px; vertical-align: top; color: #333;"><br />
<div style="margin-bottom: 12px;"><br />
<span style="background:#e0f2fe; color:#0369a1; padding:2px 6px; border-radius:4px; font-size:12px; font-weight:bold;">无基因结果时</span><br />
<strong>经验性治疗</strong>：通常首选 EP 方案（顺铂/卡铂 + 依托泊苷），参考广泛期 SCLC。<br />
</div><br />
<div><br />
<span style="background:#f0fdf4; color:#15803d; padding:2px 6px; border-radius:4px; font-size:12px; font-weight:bold;">有基因结果时</span><br />
<strong>精准化疗</strong>：<br><br />
• <strong>RB1 缺失</strong> → EP 方案。<br><br />
• <strong>RB1 野生型/KRAS+</strong> → 培美曲塞/紫杉醇 + 铂类。<br><br />
• <strong>免疫治疗</strong>：对于 PD-L1 高表达或 TMB 高的 NSCLC 样型，可考虑免疫联合化疗。<br />
</div><br />
</td><br />
</tr><br />
</table><br />
</div><br />
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<div style="margin-top: 40px; padding-top: 20px; border-top: 1px solid #e2e8f0;"><br />
<h3 style="font-size: 18px; color: #1e40af; margin-bottom: 15px;">权威参考文献 (Verified)</h3><br />
<ol style="font-size: 14px; color: #555; padding-left: 20px;"><br />
<li style="margin-bottom: 8px;"><br />
<strong>Rekhtman N, et al.</strong> Next-Generation Sequencing of Pulmonary Large Cell Neuroendocrine Carcinoma. <em>Clinical Cancer Research</em>, 2016. (确立了 LCNEC 的两种分子亚型)<br />
</li><br />
<li style="margin-bottom: 8px;"><br />
<strong>Derks JL, et al.</strong> Clinical outcomes of emerging therapeutic targets in large cell neuroendocrine carcinoma. <em>Journal of Thoracic Oncology</em>, 2024. (临床回顾性研究，证实了分型治疗的获益)<br />
</li><br />
<li style="margin-bottom: 8px;"><br />
<strong>NCCN Clinical Practice Guidelines in Oncology.</strong> <em>Neuroendocrine and Adrenal Tumors. Version 1.2026.</em><br />
</li><br />
<li style="margin-bottom: 8px;"><br />
<strong>Travis WD, et al.</strong> The 2021 World Health Organization Classification of Tumors of the Lung. <em>Journal of Thoracic Oncology</em>.<br />
</li><br />
</ol><br />
</div><br />
<br />
<div style="margin-top: 30px; background-color: #f1f5f9; padding: 15px; text-align: center; border-radius: 6px; font-size: 14px; color: #475569;"><br />
<strong>知识图谱：</strong><br />
[[非小细胞肺癌]] &middot; [[小细胞肺癌]] &middot; [[TP53]] &middot; [[RB1]] &middot; [[依托泊苷]] &middot; [[神经内分泌肿瘤]]<br />
</div><br />
<br />
</div></div>
77921020