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去T - 版本历史
2026-04-07T07:31:41Z
本wiki的该页面的版本历史
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2026年2月2日 (一) 18:50 77921020
2026-02-02T18:50:12Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">←上一版本</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">2026年2月2日 (一) 18:50的版本</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l3" >第3行：</td>
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<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <div style="margin-bottom: 30px; border-bottom: 1.2px solid #e2e8f0; padding-bottom: 25px;"></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <div style="margin-bottom: 30px; border-bottom: 1.2px solid #e2e8f0; padding-bottom: 25px;"></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <p style="font-size: 1.1em; margin: 10px 0; color: #334155; text-align: justify;"></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <p style="font-size: 1.1em; margin: 10px 0; color: #334155; text-align: justify;"></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <strong>去T细胞</strong>（T-cell Depletion, TCD）是一种在异基因造血干细胞移植（allo-HSCT）中用于预防<strong>移植物抗宿主病（GVHD）</strong>的关键技术策略。T 细胞是诱发 GVHD 的主要效应细胞，该技术旨在通过物理、免疫学或药理学手段，在移植物回输给患者之前（<strong>体外去 T</strong>）或在体内（<strong>体内去 T</strong>）大幅减少 T 淋巴细胞的数量。去 T 技术是实现<strong>单倍体（半相合）移植</strong>的基石，能显著降低致死性 GVHD 的发生；然而，过度去除 T 细胞也会导致移植物抗白血病效应（GVL）的丢失，从而增加疾病复发、植入失败及重症病毒感染（如 CMV、EBV）的风险。现代策略正向“精准去 T”（如 <del class="diffchange diffchange-inline">TCR$\alpha\beta$ </del>去除）演进，力求在保留抗感染/抗肿瘤活性与预防 GVHD 之间找到最佳平衡。</div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <strong>去T细胞</strong>（T-cell Depletion, TCD）是一种在异基因造血干细胞移植（allo-HSCT）中用于预防<strong>移植物抗宿主病（GVHD）</strong>的关键技术策略。T 细胞是诱发 GVHD 的主要效应细胞，该技术旨在通过物理、免疫学或药理学手段，在移植物回输给患者之前（<strong>体外去 T</strong>）或在体内（<strong>体内去 T</strong>）大幅减少 T 淋巴细胞的数量。去 T 技术是实现<strong>单倍体（半相合）移植</strong>的基石，能显著降低致死性 GVHD 的发生；然而，过度去除 T 细胞也会导致移植物抗白血病效应（GVL）的丢失，从而增加疾病复发、植入失败及重症病毒感染（如 CMV、EBV）的风险。现代策略正向“精准去 T”（如 <ins class="diffchange diffchange-inline">TCRαβ </ins>去除）演进，力求在保留抗感染/抗肿瘤活性与预防 GVHD 之间找到最佳平衡。</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </p></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </p></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </div></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </div></div></td></tr>
<tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l32" >第32行：</td>
<td colspan="2" class="diff-lineno">第32行：</td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <th style="text-align: left; padding: 6px 12px; background-color: #f8fafc; color: #475569; border-bottom: 1px solid #e2e8f0;">体外去 T (Ex vivo)</th></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <th style="text-align: left; padding: 6px 12px; background-color: #f8fafc; color: #475569; border-bottom: 1px solid #e2e8f0;">体外去 T (Ex vivo)</th></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #0f172a;">CD34+ 阳性分选<br><del class="diffchange diffchange-inline">TCR$\alpha\beta$</del>/CD19 阴性分选</td></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #0f172a;">CD34+ 阳性分选<br><ins class="diffchange diffchange-inline">TCRαβ</ins>/CD19 阴性分选</td></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </tr></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr></div></td></tr>
<tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l70" >第70行：</td>
<td colspan="2" class="diff-lineno">第70行：</td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </tr></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: 10px; border: 1px solid #cbd5e1; font-weight: 600; background-color: #eff6ff; color: #1e40af;"><del class="diffchange diffchange-inline">第三代：TCR$\alpha\beta$ </del>去除 (Selective Depletion)</td></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: 10px; border: 1px solid #cbd5e1; font-weight: 600; background-color: #eff6ff; color: #1e40af;"><ins class="diffchange diffchange-inline">第三代：TCRαβ </ins>去除 (Selective Depletion)</td></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: 10px; border: 1px solid #cbd5e1; background-color: #eff6ff;">仅去除引起 GVHD 的 <del class="diffchange diffchange-inline">$\alpha\beta$ </del>T 细胞，<strong>保留 <del class="diffchange diffchange-inline">$\gamma\delta$ </del>T 细胞</strong>和 NK 细胞。</td></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: 10px; border: 1px solid #cbd5e1; background-color: #eff6ff;">仅去除引起 GVHD 的 <ins class="diffchange diffchange-inline">αβ </ins>T 细胞，<strong>保留 <ins class="diffchange diffchange-inline">γδ </ins>T 细胞</strong>和 NK 细胞。</td></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: 10px; border: 1px solid #cbd5e1; background-color: #eff6ff;">保留了抗病毒/白血病活性，免疫重建快，是目前<strong>半相合移植</strong>的热门选择。</td></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: 10px; border: 1px solid #cbd5e1; background-color: #eff6ff;">保留了抗病毒/白血病活性，免疫重建快，是目前<strong>半相合移植</strong>的热门选择。</td></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </tr></div></td></tr>
<tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l104" >第104行：</td>
<td colspan="2" class="diff-lineno">第104行：</td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <p style="margin: 12px 0; border-bottom: 1px solid #e2e8f0; padding-bottom: 10px;"></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <p style="margin: 12px 0; border-bottom: 1px solid #e2e8f0; padding-bottom: 10px;"></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> [2] <strong>Locatelli F, et al. (2017).</strong> <em>Effect of α/β T-cell and B-cell depletion in children with acute leukemia transplanted from a haploidentical donor.</em> <strong>[[Blood]]</strong>. <br></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> [2] <strong>Locatelli F, et al. (2017).</strong> <em>Effect of α/β T-cell and B-cell depletion in children with acute leukemia transplanted from a haploidentical donor.</em> <strong>[[Blood]]</strong>. <br></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <span style="color: #475569;">[点评]：现代精准去 T 的代表作，证实了 <del class="diffchange diffchange-inline">TCR$\alpha\beta$ </del>去除技术在儿童白血病移植中能实现极高的无病生存率和极低的 GVHD。</span></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <span style="color: #475569;">[点评]：现代精准去 T 的代表作，证实了 <ins class="diffchange diffchange-inline">TCRαβ </ins>去除技术在儿童白血病移植中能实现极高的无病生存率和极低的 GVHD。</span></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </p></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </p></div></td></tr>
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77921020
https://www.yiliao.com/index.php?title=%E5%8E%BBT&diff=316178&oldid=prev
77921020：建立内容为“<div style="padding: 0 4%; line-height: 1.8; color: #1e293b; font-family: 'Helvetica Neue', Helvetica, 'PingFang SC', Arial, sans-serif; background-color: #ffffff…”的新页面
2026-02-02T18:48:03Z
<p>建立内容为“<div style="padding: 0 4%; line-height: 1.8; color: #1e293b; font-family: 'Helvetica Neue', Helvetica, 'PingFang SC', Arial, sans-serif; background-color: #ffffff…”的新页面</p>
<p><b>新页面</b></p><div><div style="padding: 0 4%; line-height: 1.8; color: #1e293b; font-family: 'Helvetica Neue', Helvetica, 'PingFang SC', Arial, sans-serif; background-color: #ffffff; max-width: 1200px; margin: auto;"><br />
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<strong>去T细胞</strong>（T-cell Depletion, TCD）是一种在异基因造血干细胞移植（allo-HSCT）中用于预防<strong>移植物抗宿主病（GVHD）</strong>的关键技术策略。T 细胞是诱发 GVHD 的主要效应细胞，该技术旨在通过物理、免疫学或药理学手段，在移植物回输给患者之前（<strong>体外去 T</strong>）或在体内（<strong>体内去 T</strong>）大幅减少 T 淋巴细胞的数量。去 T 技术是实现<strong>单倍体（半相合）移植</strong>的基石，能显著降低致死性 GVHD 的发生；然而，过度去除 T 细胞也会导致移植物抗白血病效应（GVL）的丢失，从而增加疾病复发、植入失败及重症病毒感染（如 CMV、EBV）的风险。现代策略正向“精准去 T”（如 TCR$\alpha\beta$ 去除）演进，力求在保留抗感染/抗肿瘤活性与预防 GVHD 之间找到最佳平衡。<br />
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<div style="font-size: 0.7em; opacity: 0.85; margin-top: 4px; white-space: nowrap;">去 T 细胞治疗 (点击展开)</div><br />
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[磁珠分选]<br />
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<div style="font-size: 0.8em; color: #64748b; margin-top: 12px; font-weight: 600;">核心目标：阻断 GVHD 发生</div><br />
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<th style="text-align: left; padding: 6px 12px; background-color: #f8fafc; color: #475569; border-bottom: 1px solid #e2e8f0; width: 40%;">体内去 T (In vivo)</th><br />
<td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #0f172a;">ATG (抗胸腺细胞球蛋白)<br>Alemtuzumab (抗CD52)</td><br />
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<th style="text-align: left; padding: 6px 12px; background-color: #f8fafc; color: #475569; border-bottom: 1px solid #e2e8f0;">体外去 T (Ex vivo)</th><br />
<td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #0f172a;">CD34+ 阳性分选<br>TCR$\alpha\beta$/CD19 阴性分选</td><br />
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<th style="text-align: left; padding: 6px 12px; background-color: #f8fafc; color: #475569; border-bottom: 1px solid #e2e8f0;">主要优势</th><br />
<td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #16a34a;">降低 III-IV 度 aGVHD</td><br />
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<th style="text-align: left; padding: 6px 12px; background-color: #f8fafc; color: #475569;">主要劣势</th><br />
<td style="padding: 6px 12px; color: #e11d48;">免疫重建延迟<br>复发率升高</td><br />
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<h2 style="background: #f1f5f9; color: #0f172a; padding: 10px 18px; border-radius: 0 6px 6px 0; font-size: 1.25em; margin-top: 40px; border-left: 6px solid #0f172a; font-weight: bold;">技术演进：从“一扫而光”到“精准剔除”</h2><br />
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去 T 技术的理念经历了从粗放到精准的巨大转变。早期的非选择性去除虽然控制了 GVHD，但因同时去除了抗病毒和抗肿瘤的 T 细胞，导致患者常死于感染或复发。<br />
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<th style="padding: 12px; border: 1px solid #cbd5e1; color: #0f172a; width: 25%;">技术代际</th><br />
<th style="padding: 12px; border: 1px solid #cbd5e1; color: #475569; width: 35%;">方法原理</th><br />
<th style="padding: 12px; border: 1px solid #cbd5e1; color: #1e40af;">临床结局</th><br />
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<td style="padding: 10px; border: 1px solid #cbd5e1; font-weight: 600;">第一代：泛去 T (Pan-T Depletion)</td><br />
<td style="padding: 10px; border: 1px solid #cbd5e1;">使用大豆凝集素或 CD3 单抗去除<strong>所有</strong> T 细胞。</td><br />
<td style="padding: 10px; border: 1px solid #cbd5e1;">GVHD 极低，但<strong>植入失败</strong>和复发率极高，基本被淘汰。</td><br />
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<td style="padding: 10px; border: 1px solid #cbd5e1; font-weight: 600;">第二代：CD34+ 分选 (Positive Selection)</td><br />
<td style="padding: 10px; border: 1px solid #cbd5e1;">只富集干细胞 (CD34+)，间接去除所有免疫细胞 (T/B/NK)。</td><br />
<td style="padding: 10px; border: 1px solid #cbd5e1;">纯度高，但因缺乏 NK 和其他辅助细胞，<strong>感染致死率高</strong>。</td><br />
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<td style="padding: 10px; border: 1px solid #cbd5e1; font-weight: 600; background-color: #eff6ff; color: #1e40af;">第三代：TCR$\alpha\beta$ 去除 (Selective Depletion)</td><br />
<td style="padding: 10px; border: 1px solid #cbd5e1; background-color: #eff6ff;">仅去除引起 GVHD 的 $\alpha\beta$ T 细胞，<strong>保留 $\gamma\delta$ T 细胞</strong>和 NK 细胞。</td><br />
<td style="padding: 10px; border: 1px solid #cbd5e1; background-color: #eff6ff;">保留了抗病毒/白血病活性，免疫重建快，是目前<strong>半相合移植</strong>的热门选择。</td><br />
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<h2 style="background: #f1f5f9; color: #0f172a; padding: 10px 18px; border-radius: 0 6px 6px 0; font-size: 1.25em; margin-top: 40px; border-left: 6px solid #0f172a; font-weight: bold;">临床权衡：双刃剑效应</h2><br />
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<h3 style="margin-top: 0; color: #166534; font-size: 1.05em;">获益 (Benefit)</h3><br />
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使得 HLA 配型不合的移植（如父母供子女）成为可能；大幅减少了移植后免疫抑制剂（如环孢素）的使用时间，提高了患者早期的生存质量。<br />
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<h3 style="margin-top: 0; color: #9f1239; font-size: 1.05em;">风险 (Risk)</h3><br />
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<strong>EBV 淋巴增殖性疾病 (PTLD)</strong> 和 CMV 肺炎风险显著增加；因缺乏 T 细胞的“清道夫”作用 (GVL)，高危白血病患者极易在移植后早期复发。<br />
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<span style="color: #0f172a; font-weight: bold; font-size: 1.05em; display: inline-block; margin-bottom: 15px;">学术参考文献 [Academic Review]</span><br />
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[1] <strong>Reisner Y, Kapoor N, et al. (1981).</strong> <em>Transplantation for severe combined immunodeficiency with HLA-A,B,D,DR incompatible parental marrow cells fractionated by soybean agglutinin and sheep red blood cells.</em> <strong>[[The Lancet]]</strong>. <br><br />
<span style="color: #475569;">[点评]：历史性突破，首次报道了通过物理去 T 技术成功实现半相合骨髓移植，奠定了该领域的基石。</span><br />
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[2] <strong>Locatelli F, et al. (2017).</strong> <em>Effect of α/β T-cell and B-cell depletion in children with acute leukemia transplanted from a haploidentical donor.</em> <strong>[[Blood]]</strong>. <br><br />
<span style="color: #475569;">[点评]：现代精准去 T 的代表作，证实了 TCR$\alpha\beta$ 去除技术在儿童白血病移植中能实现极高的无病生存率和极低的 GVHD。</span><br />
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[3] <strong>Soiffer RJ, et al. (2011).</strong> <em>Prospective, randomized, double-blind, phase III clinical trial of anti-T-lymphocyte globulin to assess impact on chronic graft-versus-host disease-free survival.</em> <strong>[[Journal of Clinical Oncology]]</strong>. <br><br />
<span style="color: #475569;">[点评]：确立了体内去 T（使用 ATG）在预防慢性 GVHD 中的标准地位。</span><br />
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移植技术 · 知识图谱<br />
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<td style="width: 85px; background-color: #f8fafc; color: #334155; font-weight: 600; padding: 10px 12px; text-align: right; vertical-align: middle;">关键试剂</td><br />
<td style="padding: 10px 15px; color: #334155;">[[ATG]] (兔/马抗人胸腺) • [[Campath]] (阿仑单抗) • [[磁珠]] (CliniMACS)</td><br />
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<td style="width: 85px; background-color: #f8fafc; color: #334155; font-weight: 600; padding: 10px 12px; text-align: right; vertical-align: middle;">细胞亚群</td><br />
<td style="padding: 10px 15px; color: #334155;">[[TCRαβ]] (致GVHD) • [[TCRγδ]] (抗肿瘤/无GVHD) • [[NK细胞]]</td><br />
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<td style="width: 85px; background-color: #f8fafc; color: #334155; font-weight: 600; padding: 10px 12px; text-align: right; vertical-align: middle;">相关模式</td><br />
<td style="padding: 10px 15px; color: #334155;">[[Haplo-HSCT]] (半相合) • [[DLI]] (供者淋巴细胞输注)</td><br />
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