https://www.yiliao.com/index.php?action=history&feed=atom&title=%E5%8A%A0%E9%80%9F%E6%9C%9F%E6%85%A2%E6%80%A7%E7%B2%92%E7%BB%86%E8%83%9E%E6%80%A7%E7%99%BD%E8%A1%80%E7%97%85
加速期慢性粒细胞性白血病 - 版本历史
2026-04-25T19:24:24Z
本wiki的该页面的版本历史
MediaWiki 1.35.1
https://www.yiliao.com/index.php?title=%E5%8A%A0%E9%80%9F%E6%9C%9F%E6%85%A2%E6%80%A7%E7%B2%92%E7%BB%86%E8%83%9E%E6%80%A7%E7%99%BD%E8%A1%80%E7%97%85&diff=305175&oldid=prev
123.130.221.191：建立内容为“{{Medical}} {{Infobox Disease | Name = 加速期慢性粒细胞性白血病 | Image = | Caption = | DiseasesDB = | ICD10…”的新页面
2021-07-21T18:48:00Z
<p>建立内容为“{{Medical}} {{Infobox Disease | Name = 加速期慢性粒细胞性白血病 | Image = | Caption = | DiseasesDB = | ICD10…”的新页面</p>
<p><b>新页面</b></p><div>{{Medical}}<br />
{{Infobox Disease<br />
| Name = 加速期慢性粒细胞性白血病<br />
| Image = <br />
| Caption = <br />
| DiseasesDB = <br />
| ICD10 = <br />
| ICD9 = <br />
| ICDO = <br />
| OMIM = <br />
| MedlinePlus = <br />
| eMedicineSubj = <br />
| eMedicineTopic = <br />
| MeshID = D015465<br />
}}<br />
<br />
'''加速期慢性粒细胞性白血病'''（{{lang-en|Accelerated phase chronic myelogenous leukemia}}），是[[慢性粒细胞性白血病]]的加速期。<br />
<br />
在此阶段中，人体[[骨髓]]和[[血液]]中的[[细胞]]中有6%至30%是原始[[血细胞]]（{{lang|en|blast cell}}）。其症状预测能力很弱。一旦慢性粒细胞性白血病患者进入到加速期，症状与表现与[[急性骨髓性白血病]]患者相似。<br />
<br />
===病征===<br />
<br />
确定进入加速期的标准并不固定。几种被广泛采用的标准是来自于M.D. Anderson[[癌症]]中心<ref>Kantarjian H, Dixon D, Keating M, Talpaz M, Walters R, McCredie K, Freireich E. Characteristics of accelerated disease in chronic myelogenous leukemia. Cancer. 1988, 61 (7): 1441–6. doi:10.1002/1097-0142(19880401)61:7<1441::AID-CNCR2820610727>3.0.CO;2-C. PMID 3162181.</ref><ref>Sokal J, Baccarani M, Russo D, Tura S. Staging and prognosis in chronic myelogenous leukemia. Semin Hematol. 1988, 25 (1): 49–61. PMID 3279515.</ref> 和[[世界卫生组织]]<ref name="WHO">{{cite journal|title=Proposals and rationale for revision of the World Health Organization diagnostic criteria for polycythemia vera, essential thrombocythemia, and primary myelofibrosis: recommendations from an ad hoc international expert pane|author=Tefferi A, Thiele J, Orazi A, Kvasnicka HM, Barbui T, Hanson CA, Barosi G, Verstovsek S, Birgegard G, Mesa R, Reilly JT, Gisslinger H, Vannucchi AM, Cervantes F, Finazzi G, Hoffman R, Gilliland DG, Bloomfield CD, Vardiman JW|year=2007|journal=Blood|volume=110|issue=4|pages=1092–7|pmid=17488875|doi=10.1182/blood-2007-04-083501}}</ref><ref>Vardiman J, Harris N, Brunning R. The [[World Health Organization]] ([[WHO]]) classification of the myeloid neoplasms. Blood. 2002, 100 (7): 2292–302 [2007-09-22]. doi:10.1182/blood-2002-04-1199. PMID 12239137.</ref>。世界卫生组织标准被最广泛地采用，其定义的加速期包括以下特征：<br />
*血液或者脊髓中，[[原粒细胞]]达到10-19%<br />
*血液或者脊髓中，[[嗜碱性粒细胞]]大于20%<br />
*排除治疗因素，[[血小板]]总量小于100,000<br />
*排除治疗因素，[[血小板]]总量大于1,000,000<br />
*除费城染色体外，细胞遗传变化伴有新的变异<br />
*排除治疗因素，脾脏肿瘤或白血球总量增大<br />
<br />
如果病人呈现以上任何一种特征，均被视为进入加速期。加速期非常重要，因为其暗示疾病在恶化，并将向急变期转化。在此阶段，[[药物治疗]]通常效果甚微<ref name="WHO"/>。<br />
<br />
== 参见 ==<br />
*[[慢性粒细胞性白血病]]<br />
<br />
== 外部链接 ==<br />
* [http://www.cancer.gov/Templates/db_alpha.aspx?CdrID=46212 Accelerated phase chronic myelogenous leukemia] entry in the public domain NCI Cancer Dictionary<br />
<br />
==资料来源==<br />
<br />
{{reflist}}<br />
<br />
{{恶性髓系肿瘤}}<br />
<br />
[[Category:白血病]] [[Category:血液疾病]]<br />
==参考来源==<br />
*[http://zh.wikipedia.org/wiki/%E5%8A%A0%E9%80%9F%E6%9C%9F%E6%85%A2%E6%80%A7%E7%B2%92%E7%BB%86%E8%83%9E%E6%80%A7%E7%99%BD%E8%A1%80%E7%97%85 维基百科-加速期慢性粒细胞性白血病]</div>
123.130.221.191